Difference between revisions of "Osteoid osteoma"
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*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref> | *Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref> | ||
*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref> | *Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref> | ||
*'''Must''' be | *'''Must''' be less than 2 cm - as per WHO definition.<ref name=pmid25224389>{{Cite journal | last1 = Yalcinkaya | first1 = U. | last2 = Doganavsargil | first2 = B. | last3 = Sezak | first3 = M. | last4 = Kececi | first4 = B. | last5 = Argin | first5 = M. | last6 = Basdemir | first6 = G. | last7 = Oztop | first7 = F. | title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 319-25 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.006 | PMID = 25224389 }}</ref> ‡ | ||
**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''. | **Larger lesions with the same microscopy are ''[[osteoblastoma]]s''. | ||
Note: | |||
*‡ Previously, the [[diagnostic size cutoffs|diagnostic size cutoff]] was <=1.5 cm.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | |||
Images: | Images: | ||
Revision as of 20:46, 23 February 2016
| Osteoid osteoma | |
|---|---|
| Diagnosis in short | |
 Osteoid osteoma. H&E stain. | |
|
| |
| LM | anastomosing bony trabeculae with variable mineralization, osteoblast rimming, no nuclear atypia of osteocytes |
| LM DDx | osteoblastoma, osteosarcoma |
| Site | bone (femur > tibia > spine > elsewhere) |
|
| |
| Clinical history | pain relieved by NSAIDs |
| Symptoms | extremely painful |
| Radiology | <= 1.5 cm (larger lesion osteoblastoma) |
| Clin. DDx | osteosarcoma |
Osteoid osteoma, abbreviated OO, is benign primary bone tumour. It is grouped with the chondro-osseous tumours.
General
- Benign bone lesion.
Clinical:[1]
- Extremely painful.
- Relieved by NSAIDs.
Gross
- Bone: femur > tibia > spine > elsewhere.[2][3]
- Most common location (in bone): diaphysis.[2]
- Must be less than 2 cm - as per WHO definition.[4] ‡
- Larger lesions with the same microscopy are osteoblastomas.
Note:
- ‡ Previously, the diagnostic size cutoff was <=1.5 cm.[5]
Images:
Microscopic
Features:[1]
- Anastomosing bony trabeculae with:
- Variable mineralization.
- Mineralization (calcium phosphate) = purple on H&E stain.
- Osteoblast rimming.
- Cells line-up at edge of bone.
- Variable mineralization.
Note:
- Histomorphologically near identical/indistinguishable from osteoblastoma;[5] one needs some history to make the diagnosis.
Images
Osteoid osteoma - low mag. (WC)
Osteoid osteoma - intermed. mag. (WC)
Osteoid osteoma - high mag. (WC)
Osteoid osteoma - very high mag. (WC)
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BONE, RIGHT FEMUR, EXCISION: - OSTEOID OSTEOMA.
Micro
The sections show anastomosing bony trabeculae with variable mineralization and osteoblastic rimming. Multinucleated osteoclasts are scattered through the lesion. Hemosiderin-laden macrophages are present. No osteocyte nuclear atypia is apparent. Mitotic activity is not apparent. The osteoid is not lace-like.
See also
References
- ↑ 1.0 1.1 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 285. ISBN 978-0781740517.
- ↑ 2.0 2.1 URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.
- ↑ URL: http://www.radiologyassistant.nl/en/494e15cbf0d8d. Accessed on: 7 May 2012.
- ↑ Yalcinkaya, U.; Doganavsargil, B.; Sezak, M.; Kececi, B.; Argin, M.; Basdemir, G.; Oztop, F. (Dec 2014). "Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients.". Ann Diagn Pathol 18 (6): 319-25. doi:10.1016/j.anndiagpath.2014.08.006. PMID 25224389.
- ↑ 5.0 5.1 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 286. ISBN 978-0781740517.
- ↑ URL: http://njms2.umdnj.edu/tutorweb/gross.htm. Accessed on: 7 May 2012.