Difference between revisions of "Intramucosal colorectal carcinoma"
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[[Image:GI Organization.svg|thumb|300px|right|A diagram showing the layers of the GI tract from inside (mucosa) to outside (serosa/adventitia). (WC)]] | |||
'''Intramucosal colorectal carcinoma''' is a confusing term for ''high grade (colorectal) dysplasia'' that should be avoided.<ref name=pmid22943008>{{Cite journal | last1 = Fleming | first1 = M. | last2 = Ravula | first2 = S. | last3 = Tatishchev | first3 = SF. | last4 = Wang | first4 = HL. | title = Colorectal carcinoma: Pathologic aspects. | journal = J Gastrointest Oncol | volume = 3 | issue = 3 | pages = 153-73 | month = Sep | year = 2012 | doi = 10.3978/j.issn.2078-6891.2012.030 | PMID = 22943008 }}</ref> | '''Intramucosal colorectal carcinoma''' is a confusing term for ''high grade (colorectal) dysplasia'' that should be avoided.<ref name=pmid22943008>{{Cite journal | last1 = Fleming | first1 = M. | last2 = Ravula | first2 = S. | last3 = Tatishchev | first3 = SF. | last4 = Wang | first4 = HL. | title = Colorectal carcinoma: Pathologic aspects. | journal = J Gastrointest Oncol | volume = 3 | issue = 3 | pages = 153-73 | month = Sep | year = 2012 | doi = 10.3978/j.issn.2078-6891.2012.030 | PMID = 22943008 }}</ref> | ||
Revision as of 05:50, 3 February 2016
Intramucosal colorectal carcinoma is a confusing term for high grade (colorectal) dysplasia that should be avoided.[1]
Intramucosal rectal carcinoma, intramucosal colonic carcinoma, intramucosal colonic adenocarcinoma, intramucosal rectal adenocarcinoma and colorectal adenocarcinoma in situ redirect here.
Background
- Colorectal adenocarcinoma is defined by invasion into the submucosa.
- This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
- Rationale: atypical (cancer-like) cells in lamina propria do not have metastatic potential as there are no lymphatics in the colorectal lamina propria.[2]
See also
References
- ↑ Fleming, M.; Ravula, S.; Tatishchev, SF.; Wang, HL. (Sep 2012). "Colorectal carcinoma: Pathologic aspects.". J Gastrointest Oncol 3 (3): 153-73. doi:10.3978/j.issn.2078-6891.2012.030. PMID 22943008.
- ↑ Lewin, MR.; Fenton, H.; Burkart, AL.; Sheridan, T.; Abu-Alfa, AK.; Montgomery, EA. (Dec 2007). "Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases.". Am J Surg Pathol 31 (12): 1882-6. doi:10.1097/PAS.0b013e318057fac2. PMID 18043043.