Difference between revisions of "Atypical lung carcinoid tumour"
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'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours|lung tumour]] with a poor outcome. | |||
==General== | |||
*Approximately 20% of lung carcinoids.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP115>{{Ref WMSP|115}}</ref> | |||
*Nests of cells. | |||
**Stippled chromatin. | |||
**Mild-to-moderate amount of cytoplasm. | |||
*No necrosis/focal necrosis. | |||
*Moderate mitotic rate (2-10/[[HPF]] - definition suffers from [[HPFitis]]). | |||
DDx: | |||
*[[Typical carcinoid lung tumour]]. | |||
*[[Small cell carcinoma of the lung]]. | |||
==IHC== | |||
*Ki-67 ~17% (range 10-26%).<ref name=pmid25318848>{{Cite journal | last1 = Liu | first1 = SZ. | last2 = Staats | first2 = PN. | last3 = Goicochea | first3 = L. | last4 = Alexiev | first4 = BA. | last5 = Shah | first5 = N. | last6 = Dixon | first6 = R. | last7 = Burke | first7 = AP. | title = Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung. | journal = Diagn Pathol | volume = 9 | issue = | pages = 174 | month = | year = 2014 | doi = 10.1186/s13000-014-0174-z | PMID = 25318848 }}</ref> | |||
Note: | |||
*[[Typical lung carcinoid tumour|Typical carcinoid]] is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).<ref name=pmid25318848/> | |||
==See also== | |||
*[[Lung tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Pulmonary pathology]] | |||
Revision as of 03:51, 23 December 2015
Atypical carcinoid lung tumour, also atypical carcinoid, is an uncommon lung tumour with a poor outcome.
General
- Approximately 20% of lung carcinoids.[1]
Microscopic
Features:[2]
- Nests of cells.
- Stippled chromatin.
- Mild-to-moderate amount of cytoplasm.
- No necrosis/focal necrosis.
- Moderate mitotic rate (2-10/HPF - definition suffers from HPFitis).
DDx:
IHC
- Ki-67 ~17% (range 10-26%).[3]
Note:
- Typical carcinoid is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).[3]
See also
References
- ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 115. ISBN 978-0781765275.
- ↑ 3.0 3.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.