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| '''Poorly differentiated carcinoma of the lung''', also '''poorly differentiated lung carcinoma''', is an unclassified [[lung tumour]] with features of [[small cell carcinoma of the lung|small cell carcinoma]] and [[non-small cell lung carcinoma]].
| | #redirect [[Non-small cell lung carcinoma]] |
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| Categorically, it is grouped with [[non-small cell lung cancer]].
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| ==General==
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| *Should be used when the DDx is ''small cell carcinoma'' versus ''non-small cell carcinoma''.
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| *''Poorly differentiated carcinoma'' leaves the surgical options on the table.
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| Clinical:
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| *Radiologic findings should not be suggestive of a metastasis.
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| ==Microscopic==
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| Features:
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| *Small cell carcinoma/basaloid squamous cell carcinoma-like tumour.
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| DDx:
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| *[[Lung metastasis]] - imaging suggestive of a metastasis or a history of malignancy.
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| *[[Small cell carcinoma of the lung]].
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| *[[Squamous cell carcinoma of the lung]].
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| ==IHC==
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| *Lack of staining with [[neuroendocrine markers]] (chromogranin A -ve, synaptophysin -ve, CD56 -ve).
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| *Keratins +ve.
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| ==Sign out==
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| <pre>
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| Lung, Left Lower Lobe, Core Biopsy:
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| - POORLY DIFFERENTIATED CARCINOMA, see comment.
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| COMMENT:
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| The tumour stains as follows:
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| POSITIVE: EMA, AE1/AE3.
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| NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45, CK5/6, p63.
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| The morphology would be compatible with small cell carcinoma or basaloid
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| squamous cell carcinoma.
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| The neuroendocrine markers (chromogranin A, synaptophysin, CD56) and the squamoid
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| markers available (p63, CK5/6) are negative; thus, the tumour is not further classified.
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| </pre>
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| ==See also==
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| *[[Lung tumours]].
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| *[[Non-small cell lung carcinoma]].
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| [[Category:Lung tumours]]
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