Difference between revisions of "Oligoastrocytoma"
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Jensflorian (talk | contribs) m (→IHC: typo) |
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===IHC=== | ===IHC=== | ||
*Oligodendroglioma-like cells: | *Oligodendroglioma-like cells: MAP2 +ve (cytoplasm). | ||
*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane). | *Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane). | ||
Revision as of 06:24, 30 September 2015
Oligoastrocytoma is an uncommon neuropathology tumour that is suspected not to be a distinct entity.[1]
General
- Mixed tumour by definition.
- More sophisticated testing usually allows separation into oligodendroglioma or astrocytoma.[1]
Microscopic
Features:
- Astrocytoma-like and oligodendroglioma-like:
- Oligodendroglioma-like cells = round nucleus, peri-nuclear clearing.
- Astrocytoma-like cells = non-ovoid/elongated nucleus.
DDx:
IHC
- Oligodendroglioma-like cells: MAP2 +ve (cytoplasm).
- Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).
Others:
- Ki-67 ~10%. (???)
- p53 - focally +ve. (???)
- IDH-1 +ve. (85%)
See also
References
- ↑ 1.0 1.1 Sahm, F.; Reuss, D.; Koelsche, C.; Capper, D.; Schittenhelm, J.; Heim, S.; Jones, DT.; Pfister, SM. et al. (Oct 2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma.". Acta Neuropathol 128 (4): 551-9. doi:10.1007/s00401-014-1326-7. PMID 25143301.