Difference between revisions of "SMARCB1"
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(tweaked some more; "rhabdoid tumour" isn't completely specific - could refer to tumour with rhabdoid morphology) |
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| Line 10: | Line 10: | ||
| Use = | | Use = | ||
| Subspecial = | | Subspecial = | ||
| Pattern = | | Pattern = nuclear staining | ||
| Positive = any healthy tissue | | Positive = any healthy tissue | ||
| Negative = [[AT/RT]], [[renal rhabdoid tumour]], [[extrarenal malignant rhabdoid tumour]], [[atypical teratoid/rhabdoid tumour]], [[epithelioid sarcoma]] | | Negative = [[AT/RT]], [[renal rhabdoid tumour]], [[extrarenal malignant rhabdoid tumour]], [[atypical teratoid/rhabdoid tumour]], [[epithelioid sarcoma]] | ||
Revision as of 02:02, 23 September 2015
| SMARCB1 | |
|---|---|
| Immunostain in short | |
 INI1-ve in AT/RT. | |
| Abbreviation | SMARCB1, BAF47 |
| Normal staining pattern | nuclear staining |
| Positive | any healthy tissue |
| Negative | AT/RT, renal rhabdoid tumour, extrarenal malignant rhabdoid tumour, atypical teratoid/rhabdoid tumour, epithelioid sarcoma |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, commonly abbreviated SMARCB1 (or INI1 or BAF47), is a diagnostic immunostain, because nuclear staining is lost in some specific types of cancer shown below.
Negative
- Epithelioid sarcoma.[1]
- Extrarenal malignant rhabdoid tumour.[2]
- Renal rhabdoid tumour.
- SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.[3]
- Atypical teratoid/rhabdoid tumour.[4]
See also
References
- ↑ Hornick, Jason (2009). "Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma". American Journal of Surgical Pathology.
- ↑ Jackson EM, Sievert AJ, Gai X et al. (March 2009). "Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors". Clin. Cancer Res. 15 (6): 1923–30.
- ↑ Bishop, JA.; Antonescu, CR.; Westra, WH. (Sep 2014). "SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.". Am J Surg Pathol 38 (9): 1282-9. doi:10.1097/PAS.0000000000000285. PMID 25007146.
- ↑ Hasselblatt, M.; Isken, S.; Linge, A.; Eikmeier, K.; Jeibmann, A.; Oyen, F.; Nagel, I.; Richter, J. et al. (Feb 2013). "High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors.". Genes Chromosomes Cancer 52 (2): 185-90. doi:10.1002/gcc.22018. PMID 23074045.