Difference between revisions of "Spindle cell lesions"
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(→Malignant fibrous histiocytoma: +refs for DOG-1) |
(→Malignant fibrous histiocytoma: more notes) |
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| Line 12: | Line 12: | ||
Work-up (MSH): | Work-up (MSH): | ||
*CD34 - GIST, angiosarcoma. | *CD34 - GIST, angiosarcoma. | ||
*S100 - neural. | *S100 - neural marker, sensitive for malignant melanoma. | ||
*Desmin - smooth muscle. | *Desmin - smooth muscle. | ||
*MIB-1 - proliferation. | *MIB-1 - proliferation. | ||
*CD99 - small | *CD99 - small round cell tumours, considered "slutty", i.e. non-specific, by Dr. Fletcher; useful if membranous stain pattern = Ewing sarcoma/PNET. | ||
*Bcl-2. | *Bcl-2. | ||
*PGP 9.5. | *PGP 9.5. | ||
Revision as of 18:51, 25 May 2010
Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em.
General DDx
Spindle cells should make think:
- Nerve.
- Muscle.
- Smooth.
- Skeletal.
- Other.
Malignant fibrous histiocytoma
Work-up (MSH):
- CD34 - GIST, angiosarcoma.
- S100 - neural marker, sensitive for malignant melanoma.
- Desmin - smooth muscle.
- MIB-1 - proliferation.
- CD99 - small round cell tumours, considered "slutty", i.e. non-specific, by Dr. Fletcher; useful if membranous stain pattern = Ewing sarcoma/PNET.
- Bcl-2.
- PGP 9.5.
- SMMS - smooth muscle.
- Caldesmon - muscle.
- PDGFR - GIST.
- DOG-1 - GIST (membranous, cytoplasmic),[1] normal pancreas (islets),[1] associated with BRCA1.