Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"

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*Rare.
*Rare.
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>
*Good prognosis on scant data<ref>{{Cite journal  | last1 = Fujino | first1 = T. | last2 = Kubota | first2 = M. | last3 = Nishiyama | first3 = R. | last4 = Kanno | first4 = T. | last5 = Okada | first5 = T. | last6 = Higashi | first6 = Y. | last7 = Yamada | first7 = H. | last8 = Okamoto | first8 = E. | title = [A case of lymphoepithelioma-like carcinoma of the bladder]. | journal = Hinyokika Kiyo | volume = 60 | issue = 10 | pages = 507-11 | month = Oct | year = 2014 | doi =  | PMID = 25391783 }}</ref> - possibly poor if metastatic.


==Microscopic==
==Microscopic==

Revision as of 09:05, 6 September 2015

Lymphoepithelioma-like carcinoma of the urinary bladder
Diagnosis in short

Urinary bladder lymphoepithelioma-like carcinoma. H&E stain.
LM squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate
Subtypes subtype of urothelial carcinoma
LM DDx lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma
IHC CK34betaE12 +ve, p63 +ve/-ve, CK7 +ve/-ve, CK20 -ve, CD30 -ve
Site urinary bladder - see urothelium
Prevalence rare
Other not associated with EBV

Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]

General

  • Rare.
  • Not associated with EBV.[2]
  • Good prognosis on scant data[3] - possibly poor if metastatic.

Microscopic

Features:

  • Clusters of (cohesive) squamoid cells with:
    • Abundant dense cytoplasm.
    • Central nuclei +/- small/indistinct nucleoli.
  • Prominent lymphoid infiltrate - key feature.
  • +/-Urothelial carcinoma in situ.

DDx:

Images

  • UBLELC - low mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - high mag. (WC)

  • UBLELC - very high mag. (WC)

www:

IHC

Features:[2]

  • p53 +ve/-ve. (+ve in ~60% of cases).
  • CK34betaE12 +ve (+ve in ~75% of cases).
  • CK7 +ve/-ve (+ve in ~60% of cases).
  • p63 +ve/-ve (+ve in ~50% of cases).

Others:[2]

  • CK20 -ve.
  • TTF-1 -ve.
  • CD30 -ve.

See also

References

  1. ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
  2. ↑ 2.0 2.1 2.2 Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
  3. ↑ Fujino, T.; Kubota, M.; Nishiyama, R.; Kanno, T.; Okada, T.; Higashi, Y.; Yamada, H.; Okamoto, E. (Oct 2014). "[A case of lymphoepithelioma-like carcinoma of the bladder].". Hinyokika Kiyo 60 (10): 507-11. PMID 25391783.
  4. ↑ 4.0 4.1 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.
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