Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"
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| Caption = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]]. | | Caption = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate | ||
| Subtypes = subtype of [[urothelial carcinoma]] | | Subtypes = subtype of [[urothelial carcinoma]] | ||
| LMDDx = | | LMDDx = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 45: | Line 45: | ||
DDx: | DDx: | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
* | *[[Urothelial carcinoma]] and inflammation. | ||
*Metastatic [[lymphoepithelioma-like carcinoma]]. | *Metastatic [[lymphoepithelioma-like carcinoma]]. | ||
Revision as of 20:14, 5 September 2015
| Lymphoepithelioma-like carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Urinary bladder lymphoepithelioma-like carcinoma. H&E stain. | |
|
| |
| LM | squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate |
| Subtypes | subtype of urothelial carcinoma |
| LM DDx | lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma |
| Site | urinary bladder - see urothelium |
|
| |
| Prevalence | rare |
| Other | not associated with EBV |
Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]
General
Microscopic
Features:
- Clusters of (cohesive) squamoid cells with:
- Abundant dense cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Surrounded by a prominent lymphoid component - key feature.
DDx:
- Lymphoma.
- Urothelial carcinoma and inflammation.
- Metastatic lymphoepithelioma-like carcinoma.
Images
UBLELC - low mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - high mag. (WC)
UBLELC - very high mag. (WC)
www:
- LELC of the urinary bladder - low mag. (nih.gov).[3]
- LELC of the urinary bladder - high mag. (nih.gov).[3]
See also
References
- ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
- ↑ Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
- ↑ 3.0 3.1 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.