Difference between revisions of "Small vessel leukocytoclastic vasculitis"
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# | '''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | ||
==General== | |||
*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | |||
Clinical: | |||
*Palpable purpura, usu. lower extremity. | |||
==Microscopic== | |||
Features:<ref name=pmid18948765/> | |||
*Small upper dermis vessels with: | |||
*#Neutrophils. | |||
*#*Fragmentation of neutrophils (leukocytoclasia). | |||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | |||
Has a very broad DDx:<ref name=pmid18948765/> | |||
#Infectious: | |||
#*Bacterial. | |||
#*Viral. | |||
#*[[Fungal]]. | |||
#Vasculitic disorders: | |||
#*ANCA mediated vasculitides: | |||
#**[[Wegener granulomatosis]]. | |||
#**[[Churg-Strauss syndrome]]. | |||
#*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal | last1 = Kraft | first1 = DM. | last2 = Mckee | first2 = D. | last3 = Scott | first3 = C. | title = Henoch-Schönlein purpura: a review. | journal = Am Fam Physician | volume = 58 | issue = 2 | pages = 405-8, 411 | month = Aug | year = 1998 | doi = | PMID = 9713395 }}</ref> | |||
#*Urticarial vasculitis. | |||
#Other: | |||
#*[[Connective tissue disease]], e.g. [[mixed connective tissue disease]], [[SLE]], [[rheumatoid arthritis]]. | |||
#*[[Cryoglobulinemia]] - may be due to [[multiple myeloma]], [[hepatitis C]]; have intravascular thrombi. | |||
#*Paraneoplastic. | |||
#*Drugs. | |||
Image: | |||
*[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | |||
*[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)]. | |||
==Stains== | |||
*PAS - look for fungus. | |||
==See also== | |||
*[[Vasculitides]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Vasculitides]] | |||
Revision as of 03:19, 14 August 2015
Small vessel leukocytoclastic vasculitis, also leukocytoclastic vasculitis (abbreviated LCV), is an inflammatory process of the small blood vessel.
General
- Most common cutaneous vasculitis.[1]
Clinical:
- Palpable purpura, usu. lower extremity.
Microscopic
Features:[1]
- Small upper dermis vessels with:
- Neutrophils.
- Fragmentation of neutrophils (leukocytoclasia).
- Vessel damage: fibrin deposition (bright pink acellular stuff).
- Neutrophils.
Has a very broad DDx:[1]
- Infectious:
- Bacterial.
- Viral.
- Fungal.
- Vasculitic disorders:
- ANCA mediated vasculitides:
- Henoch–Schönlein purpura.[2]
- Urticarial vasculitis.
- Other:
- Connective tissue disease, e.g. mixed connective tissue disease, SLE, rheumatoid arthritis.
- Cryoglobulinemia - may be due to multiple myeloma, hepatitis C; have intravascular thrombi.
- Paraneoplastic.
- Drugs.
Image:
Stains
- PAS - look for fungus.
See also
References
- ↑ 1.0 1.1 1.2 Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
- ↑ Kraft, DM.; Mckee, D.; Scott, C. (Aug 1998). "Henoch-Schönlein purpura: a review.". Am Fam Physician 58 (2): 405-8, 411. PMID 9713395.