Difference between revisions of "Graft-versus-host disease"
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===General=== | ===General=== | ||
*Complication of hematopoietic stem cell transplantation, i.e. bone marrow transplantation (BMT). | *Complication of hematopoietic stem cell transplantation, i.e. bone marrow transplantation (BMT). | ||
**Affects skin, liver (bile ducts), gastrointestinal tract.<ref name=pmid15792120>{{cite journal |author=Niino D, Nakashima M, Kondo H, ''et al.'' |title=Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis |journal=Pathol. Res. Pract. |volume=200 |issue=11-12 |pages=775–81 |year=2005 |pmid=15792120 |doi= |url=}</ref><ref>{{cite journal |author=van Dijk AM, Kessler FL, Verdonck LF, ''et al.'' |title=Primary human keratinocytes as targets in predicting acute graft-versus-host disease following HLA-identical bone marrow transplantation |journal=Br. J. Haematol. |volume=111 |issue=3 |pages=791–6 |year=2000 |month=December |pmid=11122139 |doi= |url=}}</ref> | |||
*The histology of GVHD in the intestine is the same as rejection in bowel transplantation.<ref>GT. 14 January 2011.</ref> | *The histology of GVHD in the intestine is the same as rejection in bowel transplantation.<ref>GT. 14 January 2011.</ref> | ||
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*May present as diarrhea. | *May present as diarrhea. | ||
*Main DDx (clinical): infection. | *Main DDx (clinical): infection. | ||
===Microscopic (skin)=== | |||
Features:<ref name=stanford>{{cite web |url=http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html |title=Acute Graft versus Host Disease of the Skin |last1= |first1= |last2= |first2= |date= |work= |publisher= |accessdate=January 17, 2011}}</ref> | |||
#Keratinocyte apoptosis. | |||
#Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis. | |||
#Vacuolar degeneration of basal and suprabasal cells in the epidermis. | |||
====Grading<ref name=stanford/>==== | |||
*Grade I: Only vacuolar changes, no apoptosis; not treated. | |||
*Grade II: Only scattered apoptotic cells. | |||
*Grade III: Focal separation/cleft formation at the dermal-epidermal junction. | |||
*Grade IV: Extensive necrosis with degeneration of epidermis. | |||
Notes: | |||
*Same scheme applies to esophagus... it has the same structure. | |||
*Originally described in NEJM.<ref name=pmid235092>{{cite journal |author=Thomas ED, Storb R, Clift RA, ''et al.'' |title=Bone-marrow transplantation (second of two parts) |journal=N. Engl. J. Med. |volume=292 |issue=17 |pages=895–902 |year=1975 |month=April |pmid=235092 |doi=10.1056/NEJM197504242921706 |url=}}</ref> | |||
===Microscopic (intestine)=== | ===Microscopic (intestine)=== | ||
Revision as of 04:52, 18 January 2011
Graft-versus-host disease, abbreviated as GVHD, is a rare thingy seen mostly in tertiary care centres. It is a complication of hematopoietic stem cell transplantation.
General
- Complication of hematopoietic stem cell transplantation, i.e. bone marrow transplantation (BMT).
- The histology of GVHD in the intestine is the same as rejection in bowel transplantation.[3]
Clinical:
- May present as diarrhea.
- Main DDx (clinical): infection.
Microscopic (skin)
Features:[4]
- Keratinocyte apoptosis.
- Epidermotropic lymphocytic infiltrate = lymphocytes in the epidermis.
- Vacuolar degeneration of basal and suprabasal cells in the epidermis.
Grading[4]
- Grade I: Only vacuolar changes, no apoptosis; not treated.
- Grade II: Only scattered apoptotic cells.
- Grade III: Focal separation/cleft formation at the dermal-epidermal junction.
- Grade IV: Extensive necrosis with degeneration of epidermis.
Notes:
- Same scheme applies to esophagus... it has the same structure.
- Originally described in NEJM.[5]
Microscopic (intestine)
Features:[6]
- Isolated epithelial cell apoptosis - key feature.
- +/-Crypt destruction (focal or extensive).
- +/-Loss of epithelium (denudation).
Notes:
- Neutrophils should not be present.
Images:
Grading[6]
- Grade 1 = isolated epithelial cell apoptosis.
- No crypt loss/destruction.
- Grade 2 = individual crypts are lost/scatter destruction of single crypts.
- Grade 3 = foci several adjacent crypts lost.
- Grade 4 = large number of adjacent crypts lost/loss of epithelium.
Notes:
- Low-grade rejection is a diagnosis that requires a careful examination, i.e. it is subtle.
See also
References
- ↑ {{cite journal |author=Niino D, Nakashima M, Kondo H, et al. |title=Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis |journal=Pathol. Res. Pract. |volume=200 |issue=11-12 |pages=775–81 |year=2005 |pmid=15792120 |doi= |url=}
- ↑ van Dijk AM, Kessler FL, Verdonck LF, et al. (December 2000). "Primary human keratinocytes as targets in predicting acute graft-versus-host disease following HLA-identical bone marrow transplantation". Br. J. Haematol. 111 (3): 791–6. PMID 11122139.
- ↑ GT. 14 January 2011.
- ↑ 4.0 4.1 "Acute Graft versus Host Disease of the Skin". http://surgpathcriteria.stanford.edu/transplant/skinacutegvhd/printable.html. Retrieved January 17, 2011.
- ↑ Thomas ED, Storb R, Clift RA, et al. (April 1975). "Bone-marrow transplantation (second of two parts)". N. Engl. J. Med. 292 (17): 895–902. doi:10.1056/NEJM197504242921706. PMID 235092.
- ↑ 6.0 6.1 Cogbill CH, Drobyski WR, Komorowski RA (January 2011). "Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: a clinicopathological study of 17 cases". Mod. Pathol. 24 (1): 117–25. doi:10.1038/modpathol.2010.163. PMID 20953169. http://www.nature.com/modpathol/journal/v24/n1/full/modpathol2010163a.htm.