Difference between revisions of "Craniopharyngioma"
Jump to navigation
Jump to search
(→Image: +another image) |
m (→Images: remove for the moment) |
||
| Line 35: | Line 35: | ||
Image:Adamantinomatous_craniopharyngioma_-_very_low_mag.jpg | Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron) | Image:Adamantinomatous_craniopharyngioma_-_very_low_mag.jpg | Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron) | ||
Image:Adamantinomatous_craniopharyngioma_-_intermed_mag.jpg | Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron) | Image:Adamantinomatous_craniopharyngioma_-_intermed_mag.jpg | Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron) | ||
Image:Adamantinomatous_craniopharyngioma_-_high_mag.jpg | Adamantinomatous craniopharyngioma - high mag. (WC/Nephron) | <!-- Image:Adamantinomatous_craniopharyngioma_-_high_mag.jpg | Adamantinomatous craniopharyngioma - high mag. (WC/Nephron) --> | ||
Image:Adamantinomatous_craniopharyngioma_-_very_high_mag.jpg | Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron) | Image:Adamantinomatous_craniopharyngioma_-_very_high_mag.jpg | Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
Revision as of 00:37, 16 November 2014
Craniopharyngioma is a benign neuropathology tumour.
It is subdivided into papillary craniopharyngioma and adamantinomatous craniopharyngioma.
General
- Develop from remains of Rathke's pouch or squamous epithelial cell rests.[1]
Comes in two flavours:[1]
- Adamantinomatous type.
- Adults and children.
- Squamous papillary type.
- Adults individuals.[2]
- Usually solid.
Gross
- Cystic mass filled with motor oil-like fluid.[3]
- May not be seen in the papillary variant of craniopharyngioma.
Radiology:[1]
- Calcified - adamantinomatous type only.
- Solid & cystic.
Microscopic
Adamantinomatous
Features (adamantinomatous):[4]
- Well-circumscribed (or pseudoinvasive border).
- Multicystic.
- Small-to-medium sized cells with moderate amount of basophilic cytoplasm.
- Bland nuclei (with occ. small nucleoli).
- "Wet" keratin - nests of whorled keratin.
- Calcifications (non-psammomatous).
Often contain mutations in CTNNB1, encoding β-catenin[5] resulting in intranuclear β-catenin immunohistochemical positivity.
Images
Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron)
Papillary
Features (papillary):[6]
- Non-keratinized squamous epithelium (without nuclear atypia).
- Fibrovascular cores (required for papillary).
Notes:
- +/-Cilia (rare).
- +/-Goblet cell-like formations (rare).
Image
PC - intermed. mag. (WC/Nephron)
PC - high mag. (WC/Nephron)
PC - very high mag. (WC/Nephron)
www:
See also
References
- ↑ 1.0 1.1 1.2 Garnett, MR.; Puget, S.; Grill, J.; Sainte-Rose, C. (2007). "Craniopharyngioma.". Orphanet J Rare Dis 2: 18. doi:10.1186/1750-1172-2-18. PMID 17425791.
- ↑ Giangaspero, F.; Burger, PC.; Osborne, DR.; Stein, RB. (Jan 1984). "Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma").". Am J Surg Pathol 8 (1): 57-64. PMID 6696166.
- ↑ Fernandez-Miranda, JC.; Gardner, PA.; Snyderman, CH.; Devaney, KO.; Strojan, P.; Suárez, C.; Genden, EM.; Rinaldo, A. et al. (Jul 2012). "Craniopharyngioma: a pathologic, clinical, and surgical review.". Head Neck 34 (7): 1036-44. doi:10.1002/hed.21771. PMID 21584897.
- ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.
- ↑ Preda, V.; Larkin, SJ.; Karavitaki, N.; Ansorge, O.; Grossman, AB. (Oct 2014). "The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis.". Endocr Pathol. doi:10.1007/s12022-014-9341-8. PMID 25355426.
- ↑ Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 406. ISBN 978-0443069826.
- ↑ URL: http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg. Accessed on: 6 December 2010.