Difference between revisions of "Craniopharyngioma"
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*Calcifications (non-psammomatous). | *Calcifications (non-psammomatous). | ||
Often contain mutations in CTNNB1, encoding β-catenin<ref>{{Cite journal | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume = | issue = | pages = | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }} | Often contain mutations in CTNNB1, encoding β-catenin<ref>{{Cite journal | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume = | issue = | pages = | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }} | ||
{{Cite web | last = | first = | title = http://www.ncbi.nlm.nih.gov/pubmed/25355426 | url = http://www.ncbi.nlm.nih.gov/pubmed/25355426 | publisher = | date = | accessdate = 15 November 2014 }}</ref> resulting in intranuclear β-catenin immunohistochemical positivity | {{Cite web | last = | first = | title = http://www.ncbi.nlm.nih.gov/pubmed/25355426 | url = http://www.ncbi.nlm.nih.gov/pubmed/25355426 | publisher = | date = | accessdate = 15 November 2014 }}</ref> resulting in intranuclear β-catenin immunohistochemical positivity. | ||
====Images==== | ====Images==== | ||
<gallery> | <gallery> | ||
Revision as of 23:34, 15 November 2014
Craniopharyngioma is a benign neuropathology tumour.
It is subdivided into papillary craniopharyngioma and adamantinomatous craniopharyngioma.
General
- Develop from remains of Rathke's pouch or squamous epithelial cell rests.[1]
Comes in two flavours:[1]
- Adamantinomatous type.
- Adults and children.
- Squamous papillary type.
- Adults individuals.[2]
- Usually solid.
Gross
- Cystic mass filled with motor oil-like fluid.[3]
- May not be seen in the papillary variant of craniopharyngioma.
Radiology:[1]
- Calcified - adamantinomatous type only.
- Solid & cystic.
Microscopic
Adamantinomatous
Features (adamantinomatous):[4]
- Well-circumscribed (or pseudoinvasive border).
- Multicystic.
- Small-to-medium sized cells with moderate amount of basophilic cytoplasm.
- Bland nuclei (with occ. small nucleoli).
- "Wet" keratin - nests of whorled keratin.
- Calcifications (non-psammomatous).
Often contain mutations in CTNNB1, encoding β-catenin[5] resulting in intranuclear β-catenin immunohistochemical positivity.
Images
Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron)
Papillary
Features (papillary):[6]
- Non-keratinized squamous epithelium (without nuclear atypia).
- Fibrovascular cores (required for papillary).
Notes:
- +/-Cilia (rare).
- +/-Goblet cell-like formations (rare).
Image
Papillary craniopharyngioma - intermed. mag. (WC/Nephron)
Papillary craniopharyngioma - very high mag. (WC/Nephron)
www:
See also
References
- ↑ 1.0 1.1 1.2 Garnett, MR.; Puget, S.; Grill, J.; Sainte-Rose, C. (2007). "Craniopharyngioma.". Orphanet J Rare Dis 2: 18. doi:10.1186/1750-1172-2-18. PMID 17425791.
- ↑ Giangaspero, F.; Burger, PC.; Osborne, DR.; Stein, RB. (Jan 1984). "Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma").". Am J Surg Pathol 8 (1): 57-64. PMID 6696166.
- ↑ Fernandez-Miranda, JC.; Gardner, PA.; Snyderman, CH.; Devaney, KO.; Strojan, P.; Suárez, C.; Genden, EM.; Rinaldo, A. et al. (Jul 2012). "Craniopharyngioma: a pathologic, clinical, and surgical review.". Head Neck 34 (7): 1036-44. doi:10.1002/hed.21771. PMID 21584897.
- ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.
- ↑ Preda, V.; Larkin, SJ.; Karavitaki, N.; Ansorge, O.; Grossman, AB. (Oct 2014). "The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis.". Endocr Pathol. doi:10.1007/s12022-014-9341-8. PMID 25355426. "http://www.ncbi.nlm.nih.gov/pubmed/25355426". http://www.ncbi.nlm.nih.gov/pubmed/25355426. Retrieved 15 November 2014.
- ↑ Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 406. ISBN 978-0443069826.
- ↑ URL: http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg. Accessed on: 6 December 2010.