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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 19:36, 4 December 2010
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===General=== | ===General=== | ||
*[[AKA]] ''Steele-Richardson-Olszewski syndrome''. | *[[AKA]] ''Steele-Richardson-Olszewski syndrome''. | ||
*Commonly abbreviated ''PSP''. | |||
*Diagnosis: clinical.<ref name=psp_emedicine>URL: [http://emedicine.medscape.com/article/1151430-overview http://emedicine.medscape.com/article/1151430-overview]. Accessed on: 11 November 2010.</ref> | *Diagnosis: clinical.<ref name=psp_emedicine>URL: [http://emedicine.medscape.com/article/1151430-overview http://emedicine.medscape.com/article/1151430-overview]. Accessed on: 11 November 2010.</ref> | ||
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*Globose neurofibrillary tangles in neurons. | *Globose neurofibrillary tangles in neurons. | ||
*Coiled bodies in oligodendrocytes. | *Coiled bodies in oligodendrocytes. | ||
**Wire coil-like structure around the nucleus. | |||
*Tufted astrocytes. | |||
**Near impossible to see without [[IHC]] - specifically AT8. | |||
**Cellular processes filled with crap. | |||
**Star-like appearance; looks like a road network where all the roads lead to one place (Parisian star). | |||
*Grumose degeneration of the cerebellar dentate nucleus. | |||
**Granular eosinophilic material adjacent to nuclei; once thought to be pathognomonic for PSP.<ref>URL: [http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html]. Accessed on: 4 December 2010.</ref><ref>{{cite journal |author=Yamanouchi H, Yokoo H, Yuhara Y, ''et al.'' |title=An autopsy case of ornithine transcarbamylase deficiency |journal=Brain Dev. |volume=24 |issue=2 |pages=91–4 |year=2002 |month=March |pmid=11891099 |doi= |url=}}</ref> | |||
==Huntington disease== | ==Huntington disease== | ||