Difference between revisions of "Medullary breast carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(create /w cat.)
 
(split out)
Line 1: Line 1:
#redirect [[Invasive_breast_cancer#Medullary_breast_carcinoma]]
'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]].


It is also known as '''medullary carcinoma of the breast'''.
==General==
*Uncommon breast cancer subtype.
*Some pathologists very rarely make the diagnosis.{{fact}}
Epidemiology:
*Thought to have a better prognosis that no special type (NST).
*May be associated with a BRCA1 mutation.
==Gross==
*Well-circumscribed border.<ref name=pmid21071383>{{Cite journal  | last1 = Yoo | first1 = JL. | last2 = Woo | first2 = OH. | last3 = Kim | first3 = YK. | last4 = Cho | first4 = KR. | last5 = Yong | first5 = HS. | last6 = Seo | first6 = BK. | last7 = Kim | first7 = A. | last8 = Kang | first8 = EY. | title = Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? | journal = Radiographics | volume = 30 | issue = 6 | pages = 1689-702 | month = Oct | year = 2010 | doi = 10.1148/rg.306105511 | PMID = 21071383 }}</ref>
Aside - malignant well-circumscribed breast masses - radiologic DDx:<ref name=pmid21071383/>
*Medullary breast carcinoma.
*[[Mucinous breast carcinoma]].
*[[Phyllodes tumour|Malignant phyllodes tumour]].
*[[Invasive papillary carcinoma of the breast]].
==Microscopic==
Features:
#Lesion has well-circumscribed border.
#Syncytial growth pattern = clumps of cells with poorly defined cell borders.
#Lymphocytic infiltrate.
#High nuclear grade (as per Nottingham grading system).
#No tubule formation.
==IHC==
Features - typical:<ref>{{Cite journal  | last1 = Matkovic | first1 = B. | last2 = Juretic | first2 = A. | last3 = Separovic | first3 = V. | last4 = Novosel | first4 = I. | last5 = Separovic | first5 = R. | last6 = Gamulin | first6 = M. | last7 = Kruslin | first7 = B. | title = Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. | journal = Tumori | volume = 94 | issue = 6 | pages = 838-44 | month =  | year =  | doi =  | PMID = 19267102 }}</ref>
*ER -ve.
*PR -ve.
*HER2 -ve.
==See also==
*[[Invasive breast carcinoma]].
==References==
{{Reflist|2}}
[[Category:Invasive breast carcinoma]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 11:04, 14 February 2014

Medullary breast carcinoma is an uncommon form of invasive breast carcinoma.

It is also known as medullary carcinoma of the breast.

General

  • Uncommon breast cancer subtype.
  • Some pathologists very rarely make the diagnosis.[citation needed]

Epidemiology:

  • Thought to have a better prognosis that no special type (NST).
  • May be associated with a BRCA1 mutation.

Gross

  • Well-circumscribed border.[1]

Aside - malignant well-circumscribed breast masses - radiologic DDx:[1]

Microscopic

Features:

  1. Lesion has well-circumscribed border.
  2. Syncytial growth pattern = clumps of cells with poorly defined cell borders.
  3. Lymphocytic infiltrate.
  4. High nuclear grade (as per Nottingham grading system).
  5. No tubule formation.

IHC

Features - typical:[2]

  • ER -ve.
  • PR -ve.
  • HER2 -ve.

See also

References

  1. ↑ 1.0 1.1 Yoo, JL.; Woo, OH.; Kim, YK.; Cho, KR.; Yong, HS.; Seo, BK.; Kim, A.; Kang, EY. (Oct 2010). "Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas?". Radiographics 30 (6): 1689-702. doi:10.1148/rg.306105511. PMID 21071383.
  2. ↑ Matkovic, B.; Juretic, A.; Separovic, V.; Novosel, I.; Separovic, R.; Gamulin, M.; Kruslin, B.. "Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer.". Tumori 94 (6): 838-44. PMID 19267102.
Retrieved from "https://librepathology.org/w/index.php?title=Medullary_breast_carcinoma&oldid=29266"