Difference between revisions of "Secretory carcinoma of the salivary gland"
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'''Mammary analogue secretory carcinoma''', abbreviation '''MASC''', is a newly described [[malignant]] [[salivary gland]] tumour.<ref name=pmid22127547>{{Cite journal | last1 = Lei | first1 = Y. | last2 = Chiosea | first2 = SI. | title = Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. | journal = Head Neck Pathol | volume = 6 | issue = 2 | pages = 166-70 | month = Jun | year = 2012 | doi = 10.1007/s12105-011-0312-9 | PMID = 22127547 }}</ref> | '''Mammary analogue secretory carcinoma''', abbreviation '''MASC''', is a newly described [[malignant]] [[salivary gland]] tumour.<ref name=pmid22127547>{{Cite journal | last1 = Lei | first1 = Y. | last2 = Chiosea | first2 = SI. | title = Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. | journal = Head Neck Pathol | volume = 6 | issue = 2 | pages = 166-70 | month = Jun | year = 2012 | doi = 10.1007/s12105-011-0312-9 | PMID = 22127547 }}</ref> | ||
==General== | |||
*Described in pediatric patient.<ref>{{Cite journal | last1 = Rastatter | first1 = JC. | last2 = Jatana | first2 = KR. | last3 = Jennings | first3 = LJ. | last4 = Melin-Aldana | first4 = H. | title = Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. | journal = Otolaryngol Head Neck Surg | volume = 146 | issue = 3 | pages = 514-5 | month = Mar | year = 2012 | doi = 10.1177/0194599811419044 | PMID = 21873597 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Serous cells. (???) | |||
DDx: | |||
*[[Acinic cell carcinoma]] - very closely mimics. | |||
*[[Mucoepidermoid carcinoma]]. | |||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/> | |||
==Molecular== | |||
*t(12;15)(p13;q25) | |||
**Fusion of the genes ''ETV6'' and ''NTRK3''.<ref name=pmid22127547/> | |||
Note: | |||
*The translocation seen in [[congenital-infantile fibrosarcoma]]. | |||
==See also== | ==See also== | ||
| Line 5: | Line 27: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | [[Category:Salivary gland]] | ||
Revision as of 01:20, 14 February 2014
Mammary analogue secretory carcinoma, abbreviation MASC, is a newly described malignant salivary gland tumour.[1]
General
- Described in pediatric patient.[2]
Microscopic
Features:
- Serous cells. (???)
DDx:
- Acinic cell carcinoma - very closely mimics.
- Mucoepidermoid carcinoma.
Images
Molecular
- t(12;15)(p13;q25)
- Fusion of the genes ETV6 and NTRK3.[1]
Note:
- The translocation seen in congenital-infantile fibrosarcoma.
See also
References
- ↑ 1.0 1.1 1.2 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
- ↑ Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.