Difference between revisions of "Mantle cell lymphoma"
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==General== | ==General== | ||
*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref> | *Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref> | ||
GI tract - typically:<ref name=pmid22236942/> | |||
*Abdominal pain (~37% of cases) or GI bleeding (~26% of cases). | |||
==Gross== | |||
*GI tract: polypoid lesions (~50% of cases).<ref name=pmid22236942>{{Cite journal | last1 = Kim | first1 = JH. | last2 = Jung | first2 = HW. | last3 = Kang | first3 = KJ. | last4 = Min | first4 = BH. | last5 = Lee | first5 = JH. | last6 = Chang | first6 = DK. | last7 = Kim | first7 = YH. | last8 = Son | first8 = HJ. | last9 = Rhee | first9 = PL. | title = Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement. | journal = Acta Haematol | volume = 127 | issue = 3 | pages = 129-34 | month = | year = 2012 | doi = 10.1159/000333139 | PMID = 22236942 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 17:39, 26 January 2014
| Mantle cell lymphoma | |
|---|---|
| Diagnosis in short | |
 Mantle cell lymphoma. H&E stain. | |
|
| |
| LM | small monomorphic (uniform size, shape and staining) lymphoid population with abundant mitoses, +/-scattered epithelioid histiocytes (should not be confused with tingible-body macrophages), +/-sclerosed blood vessels |
| LM DDx | other small cell lymphomas (esp. MALT lymphoma), Burkitt lymphoma |
| IHC | cyclin D1 +ve, CD5 +ve, CD43 +ve, CD20 +ve, CD23 -ve |
| Molecular | t(11;14)(q13;q32) / IGH-CCND1 |
| Site | lymph node, GI tract, other sites |
|
| |
| Prevalence | not common |
| Prognosis | poor |
Mantle cell lymphoma, abbreviated MCL, is less common small cell lymphoma that is relatively aggressive when compared to other small cell lymphomas.
General
- Relatively aggressive - guarded prognosis.[1]
GI tract - typically:[2]
- Abdominal pain (~37% of cases) or GI bleeding (~26% of cases).
Gross
- GI tract: polypoid lesions (~50% of cases).[2]
Microscopic
Features:[3]
- Small monomorphic (uniform size, shape and staining) lymphoid population.
- Abundant mitoses.
- Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
- Sclerosed blood vessels.
DDx:
- Other small cell lymphomas, esp. marginal zone lymphoma.
- Burkitt's lymphoma.
Images
MCL - low mag. (WC)
MCL - intermed. mag. (WC)
MCL - low mag. - cyclin D1. (WC)
MCL - intermed. mag. - cyclin D1. (WC)
www:
IHC
Others:
- CD23 -ve.
- Positive in CLL.
Molecular
- t(11;14)(q13;q32) / IGH-CCND1.[6]
See also
References
- ↑ Hankin, RC.; Hunter, SV. (Dec 1999). "Mantle cell lymphoma.". Arch Pathol Lab Med 123 (12): 1182-8. doi:10.1043/0003-9985(1999)1231182:MCL2.0.CO;2. PMID 10583923.
- ↑ 2.0 2.1 Kim, JH.; Jung, HW.; Kang, KJ.; Min, BH.; Lee, JH.; Chang, DK.; Kim, YH.; Son, HJ. et al. (2012). "Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement.". Acta Haematol 127 (3): 129-34. doi:10.1159/000333139. PMID 22236942.
- ↑ Good, D. 17 August 2010.
- ↑ URL: http://path.upmc.edu/cases/case308/dx.html. Accessed on: 14 January 2012.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
- ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.