Difference between revisions of "Thrombotic thrombocytopenic purpura"
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==Etiology== | ==Etiology== | ||
Deficiency of ''ADAMTS13'' which may be:<ref name=Ref_PBoD8_669>{{Ref PBoD8|669}}</ref> | Deficiency of plasma enzyme ''ADAMTS13'' which may be:<ref name=Ref_PBoD8_669>{{Ref PBoD8|669}}</ref> | ||
*Inherited. | *Inherited. | ||
*Acquired (autoantibodies). | *Acquired (autoantibodies). | ||
Revision as of 04:34, 9 November 2010
Thrombotic thrombocytopenic purpura is a type of thrombotic microangiopathy.
Classic pentad
It was classically described as the pentad of:[1]
- Fever.
- Thrombocytopenia.
- Microangiopathic hemolytic anemia.
- Transient neurologic symptoms.
- Renal failure.
Mnemonic
HUS/TTP is a CRAFTY syndrome:[2]
- CNS symptoms.
- Renal failure.
- Anemia - microangiopathic hemolytic anemia.
- Fever.
- Thrombocytopenia.
- Y - no one knows "Y" it occurs.
Etiology
Deficiency of plasma enzyme ADAMTS13 which may be:[1]
- Inherited.
- Acquired (autoantibodies).
See also
References
- ↑ 1.0 1.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 669. ISBN 978-1416031215.
- ↑ URL: http://www.valuemd.com/mnemonics2.php. Accessed on: 8 November 2010.