Difference between revisions of "Xanthogranulomatous cholecystitis"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid3584484>{{Cite journal | last1 = Roberts | first1 = KM. | last2 = Parsons | first2 = MA. | title = Xanthogranulomatous cholecystitis: clinicopathological study of 13 cases. | journal = J Clin Pathol | volume = 40 | issue = 4 | pages = 412-7 | month = Apr | year = 1987 | doi = | PMID = 3584484 | PMC = 1140974 }}</ref> | Features:<ref name=pmid3584484>{{Cite journal | last1 = Roberts | first1 = KM. | last2 = Parsons | first2 = MA. | title = Xanthogranulomatous cholecystitis: clinicopathological study of 13 cases. | journal = J Clin Pathol | volume = 40 | issue = 4 | pages = 412-7 | month = Apr | year = 1987 | doi = | PMID = 3584484 | PMC = 1140974 }}</ref> | ||
*[[Granulomas]]. | |||
*Lipid-laden macrophages. | |||
*+/-Cholesterol clefts. | |||
*Inflammatory cells. | *Inflammatory cells. | ||
*Fibrosis. | *Fibrosis. | ||
* | DDx: | ||
*[[ | *[[Chronic cholecystitis]]. | ||
*[[Gallbladder cholesterolosis]]. | |||
Image: | Image: | ||
Revision as of 20:08, 26 November 2013
| Xanthogranulomatous cholecystitis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | cholesterol clefts, granulomas |
| Site | gallbladder |
|
| |
| Clin. DDx | gallbladder carcinoma, acute cholecystitis |
Xanthogranulomatous cholecystitis, abbreviated XGC, is an uncommon pathology of the gallbladder.
General
- Uncommon ~ 1-9%.[1][2]
- Approximately 2% in one series of gallbladders.[3]
- May be confused (clinically) with gallbladder carcinoma.[1][4]
Gross
Features:[5]
- Wall thickening ~ 90% of cases.
- Gallstones ~ 70% of cases.
- +/-Infiltration of surrounding tissues (liver, fat).
Imaging:
- Hypo-attenuated nodules in the gallbladder wall.[5]
Microscopic
Features:[3]
- Granulomas.
- Lipid-laden macrophages.
- +/-Cholesterol clefts.
- Inflammatory cells.
- Fibrosis.
DDx:
Image:
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GALLBLADDER, CHOLECYSTECTOMY: - XANTHOGRANULOMATOUS CHOLECYSTITIS. - CHOLELITHIASIS.
Micro
The sections show gallbladder wall with cholesterol clefts, multinucleated giant cells and mononuclear cells. No metaplasia, nuclear atypia or dysplasia is apparent.
See also
References
- ↑ 1.0 1.1 Hale, MD.; Roberts, KJ.; Hodson, J.; Scott, N.; Sheridan, M.; Toogood, GJ. (Aug 2013). "Xanthogranulomatous cholecystitis: a European and global perspective.". HPB (Oxford). doi:10.1111/hpb.12152. PMID 23991684.
- ↑ Alvi, AR.; Jalbani, I.; Murtaza, G.; Hameed, A. (Jul 2013). "Outcomes of Xanthogranulomatous cholecystitis in laparoscopic era: A retrospective Cohort study.". J Minim Access Surg 9 (3): 109-15. doi:10.4103/0972-9941.115368. PMID 24019688.
- ↑ 3.0 3.1 Roberts, KM.; Parsons, MA. (Apr 1987). "Xanthogranulomatous cholecystitis: clinicopathological study of 13 cases.". J Clin Pathol 40 (4): 412-7. PMC 1140974. PMID 3584484. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140974/.
- ↑ Martins, PN.; Sheiner, P.; Facciuto, M. (Oct 2012). "Xanthogranulomatous cholecystitis mimicking gallbladder cancer and causing obstructive cholestasis.". Hepatobiliary Pancreat Dis Int 11 (5): 549-52. PMID 23060404.
- ↑ 5.0 5.1 Zhao, F.; Lu, PX.; Yan, SX.; Wang, GF.; Yuan, J.; Zhang, SZ.; Wang, YX. (Sep 2013). "CT and MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases.". Eur J Radiol 82 (9): 1391-7. doi:10.1016/j.ejrad.2013.04.026. PMID 23726123.
- ↑ Cecava, ND.; Andrews, R. (2011). "Case report of xanthogranulomatous cholecystitis, review of its sonographic and magnetic resonance findings, and distinction from other gallbladder pathology.". J Radiol Case Rep 5 (4): 19-24. doi:10.3941/jrcr.v5i4.696. PMID 22470787.