Difference between revisions of "Sarcoidosis"

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**Anti-TNF therapy.<ref name=pmid22389903>{{Cite journal  | last1 = Tong | first1 = D. | last2 = Manolios | first2 = N. | last3 = Howe | first3 = G. | last4 = Spencer | first4 = D. | title = New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. | journal = Intern Med J | volume = 42 | issue = 1 | pages = 89-94 | month = Jan | year = 2012 | doi =  | PMID = 22389903 }}</ref>
**Anti-TNF therapy.<ref name=pmid22389903>{{Cite journal  | last1 = Tong | first1 = D. | last2 = Manolios | first2 = N. | last3 = Howe | first3 = G. | last4 = Spencer | first4 = D. | title = New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. | journal = Intern Med J | volume = 42 | issue = 1 | pages = 89-94 | month = Jan | year = 2012 | doi =  | PMID = 22389903 }}</ref>
**Ipilimumab.<ref name=pmid24124863>{{Cite journal  | last1 = Reule | first1 = RB. | last2 = North | first2 = JP. | title = Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab. | journal = J Am Acad Dermatol | volume = 69 | issue = 5 | pages = e272-3 | month = Nov | year = 2013 | doi = 10.1016/j.jaad.2013.07.028 | PMID = 24124863 }}</ref>
**Ipilimumab.<ref name=pmid24124863>{{Cite journal  | last1 = Reule | first1 = RB. | last2 = North | first2 = JP. | title = Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab. | journal = J Am Acad Dermatol | volume = 69 | issue = 5 | pages = e272-3 | month = Nov | year = 2013 | doi = 10.1016/j.jaad.2013.07.028 | PMID = 24124863 }}</ref>
*Infections.
**[[Syphilis]].<ref name=pmid19249139>{{Cite journal  | last1 = Hervier | first1 = B. | last2 = Wastiaux | first2 = H. | last3 = Freour | first3 = T. | last4 = Masseau | first4 = A. | last5 = Corvec | first5 = S. | last6 = Armingeat | first6 = T. | last7 = Hamidou | first7 = M. | title = [Sarcoidosis-like granulomatosis revealing a tertiary syphilis]. | journal = Rev Med Interne | volume = 30 | issue = 9 | pages = 806-8 | month = Sep | year = 2009 | doi = 10.1016/j.revmed.2009.01.003 | PMID = 19249139 }}</ref>
*[[Common variable immunodeficiency]].<ref name=pmid18496983>{{Cite journal  | last1 = Vultaggio | first1 = A. | last2 = Matucci | first2 = A. | last3 = Parronchi | first3 = P. | last4 = Rossi | first4 = O. | last5 = Filì | first5 = L. | last6 = Giudizi | first6 = MG. | last7 = Palandri | first7 = F. | last8 = Agostini | first8 = C. | last9 = Semenzato | first9 = G. | title = Association between sarcoidosis-like disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune system. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 24 | issue = 2 | pages = 127-33 | month = Sep | year = 2007 | doi =  | PMID = 18496983 }}
</ref>


===Images===
===Images===

Revision as of 21:30, 25 November 2013

Sarcoidosis is non-necrotizing granulomatous disease of unknown etiology. It classically associated with (pulmonary) hilar lymphadenopathy. It may be found in almost any organ, e.g. heart, appendix.

General

  • Diagnosis of exclusion - infection must be excluded.
  • Rare.

Gross

  • Bilateral lymphadenopathy ~90% of cases.

Note:

  • Radiologic differential diagnosis includes carcinomatosis.[1]

Microscopic

Features:

  • Granulomata, well-formed, non-necrotizing.
    • Negative for microorganisms with special stains (PAS-D, GMS, AFB).
  • Usu. minimal (lymphoid) inflammation; sarcoid granulomas are known as "naked granulomas".[2]
  • In lung: interstitial location.

DDx:

Images

  • Sarcoidosis - lung. (WC)

  • Granulomata in sarcoidosis with asteroid bodies. (WC)

www:

Stains

  • ZN -ve.
  • PASD -ve.
  • GMS -ve.

Note:

  • Done to r/o infection.

Sign out

  • Should be something like sarcoid-like granulomas and clinical correlation required.

See also

References

  1. ↑ URL: http://www.radiologyassistant.nl/en/46b480a6e4bdc. Accessed on: 23 May 2010.
  2. ↑ Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
  3. ↑ Tong, D.; Manolios, N.; Howe, G.; Spencer, D. (Jan 2012). "New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication.". Intern Med J 42 (1): 89-94. PMID 22389903.
  4. ↑ Reule, RB.; North, JP. (Nov 2013). "Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab.". J Am Acad Dermatol 69 (5): e272-3. doi:10.1016/j.jaad.2013.07.028. PMID 24124863.
  5. ↑ Hervier, B.; Wastiaux, H.; Freour, T.; Masseau, A.; Corvec, S.; Armingeat, T.; Hamidou, M. (Sep 2009). "[Sarcoidosis-like granulomatosis revealing a tertiary syphilis].". Rev Med Interne 30 (9): 806-8. doi:10.1016/j.revmed.2009.01.003. PMID 19249139.
  6. ↑ Vultaggio, A.; Matucci, A.; Parronchi, P.; Rossi, O.; Filì, L.; Giudizi, MG.; Palandri, F.; Agostini, C. et al. (Sep 2007). "Association between sarcoidosis-like disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune system.". Sarcoidosis Vasc Diffuse Lung Dis 24 (2): 127-33. PMID 18496983.
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