Difference between revisions of "Polymorphous adenocarcinoma"
Jump to navigation
Jump to search
(more) |
|||
| Line 51: | Line 51: | ||
Note: | Note: | ||
*'''Always | *'''Always''' a low-grade tumour - by definition. | ||
DDx: | DDx: | ||
| Line 64: | Line 64: | ||
Image:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg | PLGA - high mag. (WC/Nephron) | Image:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg | PLGA - high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23320410>{{Cite journal | last1 = de Araujo | first1 = VC. | last2 = Passador-Santos | first2 = F. | last3 = Turssi | first3 = C. | last4 = Soares | first4 = AB. | last5 = de Araujo | first5 = NS. | title = Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. | journal = Diagn Pathol | volume = 8 | issue = | pages = 6 | month = | year = 2013 | doi = 10.1186/1746-1596-8-6 | PMID = 23320410 }}</ref> | Features:<ref name=pmid23320410>{{Cite journal | last1 = de Araujo | first1 = VC. | last2 = Passador-Santos | first2 = F. | last3 = Turssi | first3 = C. | last4 = Soares | first4 = AB. | last5 = de Araujo | first5 = NS. | title = Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. | journal = Diagn Pathol | volume = 8 | issue = | pages = 6 | month = | year = 2013 | doi = 10.1186/1746-1596-8-6 | PMID = 23320410 }}</ref> | ||
Revision as of 16:59, 23 November 2013
| Polymorphous adenocarcinoma | |
|---|---|
| Diagnosis in short | |
 PLGA. H&E stain. | |
|
| |
| LM | low-grade cytology - nuclei ovoid & small, small nucleoli, powdery chromatin (papillary thyroid carcinoma-like appearance); eosinophilic cytoplasm; variable architecture - often small nests, classically has whorling ("eye-of-storm") pattern and single file pattern |
| LM DDx | adenoid cystic carcinoma, pleomorphic adenoma, cribriform adenocarcinoma of the minor salivary gland |
| IHC | S-100 +ve, CK7 +ve, vimentin +ve |
| Site | oral cavity, salivary gland |
|
| |
| Prevalence | uncommon (varies by study) |
| Prognosis | good |
Polymorphous low-grade adenocarcinoma, abbreviated PLGA, is a rare malignant salivary gland tumour.
General
- Female:male ~= 2:1.
- Older people ~50-70 years old.
- Large variably in the prevalence reported - suggests a lacking of reproducibility in the diagnosis.[1]
- Slow growing - metastases rare - prognosis good.[2][3]
Gross
- Tumour of the minor salivary glands.[4]
- Almost exclusively in the oral cavity - usually palate.[2]
Microscopic
Features:[5]
- Architecture: often small nests, may be targetoid.
- Classically has whorling with eye-of-storm & single file.
- Cytologically monotonous (uniform) with variable architecture - key feature.
- Nucleus: ovoid & small, small nucleoli, powdery chromatin.
- Papillary thyroid carcinoma-like appearance.
- Cytoplasm: eosinophilic.
- Nucleus: ovoid & small, small nucleoli, powdery chromatin.
- Indistinct cell borders.
Note:
- Always a low-grade tumour - by definition.
DDx:
- Adenoid cystic carcinoma.
- Pleomorphic adenoma.
- Cribriform adenocarcinoma of the minor salivary gland.[6]
Images
PLGA - very low mag. (WC/Nephron)
PLGA - high mag. (WC/Nephron)
IHC
Features:[1]
- S-100 +ve.
- CK7 +ve.
- Vimentin +ve.
Others:
- GFAP +ve/-ve.
- BCL2 +ve/-ve.
- Generally negative for myoepithelial markers (calponin, actin) - useful if negative.
See also
References
- ↑ 1.0 1.1 de Araujo, VC.; Passador-Santos, F.; Turssi, C.; Soares, AB.; de Araujo, NS. (2013). "Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists.". Diagn Pathol 8: 6. doi:10.1186/1746-1596-8-6. PMID 23320410.
- ↑ 2.0 2.1 Paleri, V.; Robinson, M.; Bradley, P. (Apr 2008). "Polymorphous low-grade adenocarcinoma of the head and neck.". Curr Opin Otolaryngol Head Neck Surg 16 (2): 163-9. doi:10.1097/MOO.0b013e3282f70441. PMID 18327037.
- ↑ Fife, TA.; Smith, B.; Sullivan, CA.; Browne, JD.; Waltonen, JD.. "Polymorphous low-grade adenocarcinoma: a 17 patient case series.". Am J Otolaryngol 34 (5): 445-8. doi:10.1016/j.amjoto.2013.03.012. PMID 23618791.
- ↑ Andreu-Barasoain, M.; Vicente-Martín, FJ.; Gómez de la Fuente, E.; Salamanca-Santamaría, J.; Pampín-Franco, A.; López-Estebaranz, JL. (2013). "Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor.". Dermatol Online J 19 (8): 19265. PMID 24021444.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 74. ISBN 978-0781765275.
- ↑ Skalova, A.; Sima, R.; Kaspirkova-Nemcova, J.; Simpson, RH.; Elmberger, G.; Leivo, I.; Di Palma, S.; Jirasek, T. et al. (Aug 2011). "Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity.". Am J Surg Pathol 35 (8): 1168-76. doi:10.1097/PAS.0b013e31821e1f54. PMID 21716087.