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Difference between revisions of "Neuropathology"
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→Inclusion bodies
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**Eosinophilic cytoplasmic inclusion - composed mostly of alpha-synuclein.<ref name=pmid15235805>{{cite journal |author=Marui W, Iseki E, Kato M, Akatsu H, Kosaka K |title=Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease |journal=Acta Neuropathol. |volume=108 |issue=2 |pages=121–8 |year=2004 |month=August |pmid=15235805 |doi=10.1007/s00401-004-0869-4 |url=}}</ref> | **Eosinophilic cytoplasmic inclusion - composed mostly of alpha-synuclein.<ref name=pmid15235805>{{cite journal |author=Marui W, Iseki E, Kato M, Akatsu H, Kosaka K |title=Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease |journal=Acta Neuropathol. |volume=108 |issue=2 |pages=121–8 |year=2004 |month=August |pmid=15235805 |doi=10.1007/s00401-004-0869-4 |url=}}</ref> | ||
**Image: [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG Lewy body (WC)]. | **Image: [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG Lewy body (WC)]. | ||
====Table==== | |||
{| class="wikitable" | |||
| Feature | |||
| Appearance | |||
| Associated disease | |||
| Comment | |||
| Image | |||
|- | |||
| Grumous bodies<br>[[AKA]] granular bodies | |||
| granular and eosinophilic ~50 micrometers | |||
| neurodegenerative disease, neuroaxonal dystrophies, aging | |||
| Comment | |||
| Image | |||
|- | |||
| Cowdry type 1<br>AKA Cowdry type A | |||
| eosinophilic & round + halo | |||
| Herpes simplex virus | |||
| Can be confused with <br>Lewy body, Marinesco body | |||
| Image | |||
|- | |||
| Lewy body | |||
| Cytoplasmic thingy | |||
| Lewy body dementia | |||
| Comment | |||
| [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG] | |||
|- | |||
| Lafora body | |||
| concentric calcification | |||
| Associated disease | |||
| look like corpora amylacea | |||
| Image | |||
|- | |||
| Lipofuscin | |||
| Yellow & granular | |||
| Aging | |||
| olive, dendate | |||
| Image | |||
|- | |||
| Negri body | |||
| small eosinophic bodies | |||
| rabies | |||
| found in hippocampal neurons and Purkinje cells | |||
| [http://commons.wikimedia.org/wiki/File:Rabies_encephalitis_Negri_bodies_PHIL_3377_lores.jpg] | |||
|- | |||
| Hirano body | |||
| Appearance | |||
| ALS, Parkinson's disease | |||
| actin crystals, may look like capillaries | |||
| Image | |||
|- | |||
| Neurofibrillary tangles | |||
| flame-shaped cytoplasmic thingy<br>~30 micrometers | |||
| aging, Alzheimer's disease | |||
| seen with silver stain | |||
| Image | |||
|- | |||
| Pick bodies | |||
| Appearance | |||
| Associated disease | |||
| Comment | |||
| Image | |||
|- | |||
| Bunina body | |||
| size of Nissl granules | |||
| Associated disease | |||
| Comment | |||
| Image | |||
|- | |||
<!-- | Feature | |||
| Appearance | |||
| Associated disease | |||
| Comment | |||
| Image | |||
|- --> | |||
|} | |||
==Ring enhancing lesions== | ==Ring enhancing lesions== | ||