Difference between revisions of "Traditional serrated adenoma"
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'''Traditional_serrated_adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]]. | '''Traditional_serrated_adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]]. | ||
Before the [[sessile serrated adenoma]]s were recognized, these lesions were known as '''[[serrated adenoma]]s'''.<ref name=pmid20656251>{{Cite journal | last1 = Noffsinger | first1 = AE. | last2 = Hart | first2 = J. | title = Serrated adenoma: a distinct form of non-polypoid colorectal neoplasia? | journal = Gastrointest Endosc Clin N Am | volume = 20 | issue = 3 | pages = 543-63 | month = Jul | year = 2010 | doi = 10.1016/j.giec.2010.03.012 | PMID = 20656251 }}</ref> | |||
==General== | ==General== | ||
*Very rare. | *Very rare. | ||
*Pre-malignant.<ref name=pmid23208018>{{Cite journal | last1 = Rosty | first1 = C. | last2 = Hewett | first2 = DG. | last3 = Brown | first3 = IS. | last4 = Leggett | first4 = BA. | last5 = Whitehall | first5 = VL. | title = Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. | journal = J Gastroenterol | volume = 48 | issue = 3 | pages = 287-302 | month = Mar | year = 2013 | doi = 10.1007/s00535-012-0720-y | PMID = 23208018 }}</ref> | |||
==Gross== | ==Gross== | ||
*Usually left colon. | *Polypoid mass. | ||
*Usually in the left colon. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 19:36, 9 July 2013
| Traditional serrated adenoma | |
|---|---|
| Diagnosis in short | |
 | |
|
| |
| LM | serrated, eosinophilic cytoplasm, villous-like architecture |
| LM DDx | villous adenoma |
| Site | colon - usu. left side / gastrointestinal polyps |
|
| |
Traditional_serrated_adenoma, abbreviated TSA, are a rare type of gastrointestinal polyp.
Before the sessile serrated adenomas were recognized, these lesions were known as serrated adenomas.[1]
General
- Very rare.
- Pre-malignant.[2]
Gross
- Polypoid mass.
- Usually in the left colon.
Microscopic
Features:[3]
- Serrated - essential.
- Eosinophilic cytoplasm - key feature.
- Nuclear atypia as in tubular adenoma.
- Nuclear hyperchromasia, enlargement and pseudostratification.
- Villous-like architecture.
DDx:
Images
TSA - low mag. (WC/Nephron)
TSA - intermed. mag. (WC/Nephron)
TSA - very high mag. (WC/Nephron)
See also
References
- ↑ Noffsinger, AE.; Hart, J. (Jul 2010). "Serrated adenoma: a distinct form of non-polypoid colorectal neoplasia?". Gastrointest Endosc Clin N Am 20 (3): 543-63. doi:10.1016/j.giec.2010.03.012. PMID 20656251.
- ↑ Rosty, C.; Hewett, DG.; Brown, IS.; Leggett, BA.; Whitehall, VL. (Mar 2013). "Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.". J Gastroenterol 48 (3): 287-302. doi:10.1007/s00535-012-0720-y. PMID 23208018.
- ↑ Li SC, Burgart L (March 2007). "Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps". Arch. Pathol. Lab. Med. 131 (3): 440-5. PMID 17516746. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=131&page=440.