Difference between revisions of "Desmoplasia"
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'''Desmoplasia''' | '''Desmoplasia''' is the formation if fibrous connective tissue.<ref>URL: [http://www.merriam-webster.com/medical/desmoplasia http://www.merriam-webster.com/medical/desmoplasia]. Accessed on: 2 May 2013.</ref> It is also known as the '''desmoplastic response''' and '''desmoplastic stromal response'''. | ||
It is a stromal change that in the context of dysplasia supports the diagnosis of invasive carcinoma. | |||
==Microscopic== | ==Microscopic== | ||
Feature: | Feature: | ||
*Large (plump) spindle cells with relatively pale nuclei | *Increased stromal cellularity - '''key feature'''. | ||
**Large (plump) spindle cells with relatively pale nuclei. | |||
*Edema - pale spaces between the cells. | *Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref> | ||
DDx: | DDx: | ||
| Line 15: | Line 17: | ||
==See also== | ==See also== | ||
*[[Pseudoinvasion]]. | *[[Pseudoinvasion]]. | ||
*[[Cancer]]. | |||
*[[Basics]]. | |||
==References== | ==References== | ||
Revision as of 20:52, 2 May 2013
Desmoplasia is the formation if fibrous connective tissue.[1] It is also known as the desmoplastic response and desmoplastic stromal response.
It is a stromal change that in the context of dysplasia supports the diagnosis of invasive carcinoma.
Microscopic
Feature:
- Increased stromal cellularity - key feature.
- Large (plump) spindle cells with relatively pale nuclei.
- Edema - pale spaces between the cells - may be apparent at low power.[2]
DDx:
Image:
See also
References
- ↑ URL: http://www.merriam-webster.com/medical/desmoplasia. Accessed on: 2 May 2013.
- ↑ Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 15. ISBN 978-0387744858.