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Difference between revisions of "Sjögren syndrome"
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→Grading - historical
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**One or more is considered significant.<ref name=pmid12006334/> | **One or more is considered significant.<ref name=pmid12006334/> | ||
====Grading | ====Grading==== | ||
In the past lesions were graded with the ''Chisholm-Mason classification''.<ref name=pmid15956090>{{Cite journal | last1 = Ramos-Casals | first1 = M. | last2 = Font | first2 = J. | title = Primary Sjögren's syndrome: current and emergent aetiopathogenic concepts. | journal = Rheumatology (Oxford) | volume = 44 | issue = 11 | pages = 1354-67 | month = Nov | year = 2005 | doi = 10.1093/rheumatology/keh714 | PMID = 15956090 | url = http://rheumatology.oxfordjournals.org/content/44/11/1354.long }}</ref> | In the past lesions were graded with the ''Chisholm-Mason classification''.<ref name=pmid15956090>{{Cite journal | last1 = Ramos-Casals | first1 = M. | last2 = Font | first2 = J. | title = Primary Sjögren's syndrome: current and emergent aetiopathogenic concepts. | journal = Rheumatology (Oxford) | volume = 44 | issue = 11 | pages = 1354-67 | month = Nov | year = 2005 | doi = 10.1093/rheumatology/keh714 | PMID = 15956090 | url = http://rheumatology.oxfordjournals.org/content/44/11/1354.long }}</ref><ref>{{Cite journal | last1 = Chisholm | first1 = DM. | last2 = Mason | first2 = DK. | title = Labial salivary gland biopsy in Sjögren's disease. | journal = J Clin Pathol | volume = 21 | issue = 5 | pages = 656-60 | month = Sep | year = 1968 | doi = | PMID = 5697370 | PMC = 473887 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC473887/?tool=pubmed }}</ref> The ''Chisholm-Mason classification'' is based on assessing 4 mm<sup>2</sup> area of salivary gland tissue and depends on the abundance and aggregation of lymphocytes. | ||
It is | It is compares to Daniels-Whitcher grading as follows: | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! Lymphocytes | ! Lymphocytes | ||
! Daniels-Whitcher <br>grade | |||
! Chisholm-Mason <br>grade | |||
|- | |- | ||
| slight infiltrate | | slight infiltrate | ||
| mild | |||
| 1 | |||
|- | |- | ||
| moderate infiltrate or less than one focus † | |||
| intermediate | |||
| 2 | | 2 | ||
|- | |- | ||
| one focus † | |||
| severe | |||
| 3 | | 3 | ||
|- | |- | ||
| more than one focus † | |||
| severe | |||
| 4 | | 4 | ||
|} | |} | ||
† Focus = aggregrate of 50 lymphocytes. | † Focus = an aggregrate of 50 lymphocytes or more. | ||
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