Difference between revisions of "Chronic granulomatous disease"
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'''Chronic granulomatous disease''' is a | '''Chronic granulomatous disease''', abbreviated '''CGD''', is a specific diagnosis; it should ''not'' be understood as a granulomatous disease that is of a long duration. | ||
CGD is disorder of neutrophils<ref name=pmid19098859/> and typically leads to widespread [[granuloma]]s.<ref name=pmid21116026>{{cite journal |author=Seger RA |title=Chronic granulomatous disease: recent advances in pathophysiology and treatment |journal=Neth J Med |volume=68 |issue=11 |pages=334–40 |year=2010 |month=November |pmid=21116026 |doi= |url=}}</ref> | |||
==General== | ==General== | ||
*Five different genetic defects have been identified that cause the disease. | *Five different genetic defects have been identified that cause the disease. | ||
* | *Individual with the condition have an increased susceptibility to infections. | ||
==Microscopic== | ==Microscopic== | ||
| Line 10: | Line 12: | ||
DDx: | DDx: | ||
*[[Crohn's disease]] - essentially indistinguishable histomorphologically in the GI tract. | *[[Crohn's disease]] - essentially indistinguishable histomorphologically in the GI tract.{{Cite journal | last1 = Marks | first1 = DJ. | last2 = Miyagi | first2 = K. | last3 = Rahman | first3 = FZ. | last4 = Novelli | first4 = M. | last5 = Bloom | first5 = SL. | last6 = Segal | first6 = AW. | title = Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease. | journal = Am J Gastroenterol | volume = 104 | issue = 1 | pages = 117-24 | month = Jan | year = 2009 | doi = 10.1038/ajg.2008.72 | PMID = 19098859 }}</ref> | ||
==References== | ==References== | ||
Revision as of 04:17, 7 March 2013
Chronic granulomatous disease, abbreviated CGD, is a specific diagnosis; it should not be understood as a granulomatous disease that is of a long duration.
CGD is disorder of neutrophils[1] and typically leads to widespread granulomas.[2]
General
- Five different genetic defects have been identified that cause the disease.
- Individual with the condition have an increased susceptibility to infections.
Microscopic
Features:
- Granulomas - see Basics.
DDx:
- Crohn's disease - essentially indistinguishable histomorphologically in the GI tract.Marks, DJ.; Miyagi, K.; Rahman, FZ.; Novelli, M.; Bloom, SL.; Segal, AW. (Jan 2009). "Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.". Am J Gastroenterol 104 (1): 117-24. doi:10.1038/ajg.2008.72. PMID 19098859.</ref>