Difference between revisions of "Hemolytic uremic syndrome"
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'''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | '''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | ||
*Microangiopathic hemolytic anemia | *Microangiopathic hemolytic anemia. | ||
*Thrombocytopenia | **Microangiopathic = disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> | ||
*Thrombocytopenia = low platelet count. | |||
*Acute renal failure. | *Acute renal failure. | ||
Revision as of 19:39, 9 September 2010
Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]
- Microangiopathic hemolytic anemia.
- Microangiopathic = disease affecting small blood vessels.[2]
- Thrombocytopenia = low platelet count.
- Acute renal failure.
Etiology
- Rare (uncooked) hamburger.
- E. coli serotype O157:H7.
- Verotoxins from E. coli O157:H7 --> endothelial injury.[3]
Relation to thrombotic thrombocytopenic purpura (TTP)
- TTP is the main (clinical) DDx of HUS.
- It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
- Both are classified as thrombotic microangiopathies.[4]
See also
References
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
- ↑ URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
- ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.