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Difference between revisions of "Ovarian tumours"
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→Surface epithelial tumours: tweak
(→Surface epithelial tumours: tweak) |
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'''Where to start when considering a malignant (epithelial) tumour of the ovary:''' | '''Where to start when considering a malignant (epithelial) tumour of the ovary:''' | ||
{| class="wikitable" | {| class="wikitable sortable" | ||
!Features | |||
! Serous | |||
! Endometrioid | |||
! Mucinous | |||
|- | |- | ||
| | |Histology | ||
| low grade: cilia, columnar cells, [[psammoma bodies]], papillary arch.; high grade: marked nuclear pleomorphism, prominent [[red nucleoli]], [[psammoma bodies]] | |||
| gland forming - esp. cribriforming, endometrium-like | |||
| mucinous glands, colon-like | |||
|- | |- | ||
|Differentiators | |Differentiators | ||
| cilia, [[psammoma bodies]] | |||
| squamous metaplasia | |||
| mucin, often lack of [[necrosis]] | |||
|- | |- | ||
|Associations | |Associations | ||
| atrophy | |||
| [[endometriosis]], [[endometrial hyperplasia]] | |||
| (?) | |||
|- | |- | ||
|Typical age | |Typical age | ||
| usually 60s+ | |||
| 40-60 | |||
| varies (?) | |||
|- | |- | ||
|Grade | |Grade | ||
| typically high grade | |||
| typically low grade | |||
| often low | |||
|- | |- | ||
|IHC | |IHC | ||
| p53 +ve (diffuse), WT-1 +ve, CA-125 +ve, D2-40 +ve | |||
| WT-1 -ve | |||
| CK7 +ve, CK20 +ve (other tumours CK7 +ve, CK20 -ve) | |||
|- | |- | ||
|Main DDx | |Main DDx | ||
| poorly diff. endometrioid | |||
| serous | |||
| metastatic tumour (usually GI) | |||
|- | |- | ||
|} | |} | ||