Difference between revisions of "Electron microscopy"
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This article collection stuffs about '''electron microscopy'''. It is commonly abbreviated '''EM'''. | This article collection stuffs about '''electron microscopy'''. It is commonly abbreviated '''EM'''. | ||
=Ultrastructural findings= | |||
==Glycogen== | ==Glycogen== | ||
===General=== | |||
Seen in: | |||
*[[Glycogen storage disorders]]. | |||
*[[Ewing sarcoma]]. | |||
===Ultrastructure=== | |||
Appearance: | Appearance: | ||
*Cytoplasmic, electron dense, not bound by a membrane. | *Cytoplasmic, electron dense, not bound by a membrane. | ||
==Tubuloreticular inclusions== | ==Tubuloreticular inclusions== | ||
Abbreviated ''TRIs''. | Abbreviated ''TRIs''. | ||
===General=== | |||
Seen in: | |||
*[[Dermatomyositis]]. | |||
*[[Inclusion body myositis]]. | |||
===Ultrastructure=== | |||
Appearance: | Appearance: | ||
*Undulating tubules in the smooth ER, usu. perinuclear.<ref name=pmid19330338>{{cite journal |author=Stoltenburg-Didinger G, Genth E |title=[Dermatomyositis] |language=German |journal=Z Rheumatol |volume=68 |issue=4 |pages=287–94 |year=2009 |month=June |pmid=19330338 |doi=10.1007/s00393-008-0398-y |url=}}</ref> | *Undulating tubules in the smooth ER, usu. perinuclear.<ref name=pmid19330338>{{cite journal |author=Stoltenburg-Didinger G, Genth E |title=[Dermatomyositis] |language=German |journal=Z Rheumatol |volume=68 |issue=4 |pages=287–94 |year=2009 |month=June |pmid=19330338 |doi=10.1007/s00393-008-0398-y |url=}}</ref> | ||
==Melanosomes== | |||
===General=== | |||
Seen in: | Seen in: | ||
*[[ | *[[Melanoma]]. | ||
== | ===Ultrastructure=== | ||
Appearance: | Appearance: | ||
*Membrane bound, sausage-like shape. | *Membrane bound, sausage-like shape. | ||
| Line 24: | Line 34: | ||
Image(s): | Image(s): | ||
*[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)]. | *[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)]. | ||
==Neurosecretory granules== | ==Neurosecretory granules== | ||
| Line 45: | Line 52: | ||
==Birbeck granules== | ==Birbeck granules== | ||
===General=== | |||
*Seen in [[Langerhans cell histiocytosis]]. | *Seen in [[Langerhans cell histiocytosis]]. | ||
===Ultrastructure=== | |||
Appearance: | Appearance: | ||
*Electron dense, cytoplasmic tennis racket-like body. | *Electron dense, cytoplasmic tennis racket-like body. | ||
| Line 54: | Line 63: | ||
**Usually... only the handle of the tennis racket is well seen. | **Usually... only the handle of the tennis racket is well seen. | ||
=Specific diagnoses= | |||
==Malignant mesothelioma== | ==Malignant mesothelioma== | ||
{{Main|Malignant mesothelioma}} | {{Main|Malignant mesothelioma}} | ||
| Line 60: | Line 70: | ||
*Quantity of intermediate filaments -- mesothelioma have more. | *Quantity of intermediate filaments -- mesothelioma have more. | ||
=See also= | |||
*[[Microscope]]. | *[[Microscope]]. | ||
*[[Medical kidney diseases]]. | *[[Medical kidney diseases]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
=External links= | |||
*[http://www.uni-mainz.de/FB/Medizin/Anatomie/workshop/EM/EMGlykogenE.html Electron microscopy atlas (uni-mainz.de)]. | *[http://www.uni-mainz.de/FB/Medizin/Anatomie/workshop/EM/EMGlykogenE.html Electron microscopy atlas (uni-mainz.de)]. | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
Revision as of 02:07, 5 May 2012
This article collection stuffs about electron microscopy. It is commonly abbreviated EM.
Ultrastructural findings
Glycogen
General
Seen in:
Ultrastructure
Appearance:
- Cytoplasmic, electron dense, not bound by a membrane.
Tubuloreticular inclusions
Abbreviated TRIs.
General
Seen in:
Ultrastructure
Appearance:
- Undulating tubules in the smooth ER, usu. perinuclear.[1]
Melanosomes
General
Seen in:
Ultrastructure
Appearance:
- Membrane bound, sausage-like shape.
Image(s):
Neurosecretory granules
- AKA dense-core granules.
General
Seen in:
Ultrastructure
Appearance:[3]
- Round membrane bound, granular core.
- Size: 100-400 nm.
Image(s):
Birbeck granules
General
- Seen in Langerhans cell histiocytosis.
Ultrastructure
Appearance:
- Electron dense, cytoplasmic tennis racket-like body.
Image(s):
- Birbeck granules (photobucket.com).
- Usually... only the handle of the tennis racket is well seen.
Specific diagnoses
Malignant mesothelioma
Main article: Malignant mesothelioma
Several EM features can be useful to distinguish mesothelioma from adenocarcinoma as per Warhol et al:[4]
- Microvillous length -- longer in mesothelioma.
- Quantity of intermediate filaments -- mesothelioma have more.
See also
References
- ↑ Stoltenburg-Didinger G, Genth E (June 2009). "[Dermatomyositis]" (in German). Z Rheumatol 68 (4): 287–94. doi:10.1007/s00393-008-0398-y. PMID 19330338.
- ↑ Gil-Moreno, A.; Garcia-Jiménez, A.; González-Bosquet, J.; Esteller, M.; Castellví-Vives, J.; Martínez Palones, JM.; Xercavins, J. (Mar 1997). "Merkel cell carcinoma of the vulva.". Gynecol Oncol 64 (3): 526-32. PMID 9062165.
- ↑ URL: http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html. Accessed on: 11 February 2011.
- ↑ Warhol, MJ.; Hickey, WF.; Corson, JM. (Jun 1982). "Malignant mesothelioma: ultrastructural distinction from adenocarcinoma.". Am J Surg Pathol 6 (4): 307-14. PMID 6287872.