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Difference between revisions of "Pediatric gastrointestinal pathology"
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Pediatric gastrointestinal pathology (view source)
Revision as of 14:44, 7 April 2012
, 14:44, 7 April 2012→IHC: tweak
(→Aganglionosis: +gross) |
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===IHC=== | ===IHC=== | ||
Features:<ref name=pmid1640323>{{Cite journal | last1 = Luider | first1 = TM. | last2 = van Dommelen | first2 = MW. | last3 = Tibboel | first3 = D. | last4 = Meijers | first4 = JH. | last5 = Ten Kate | first5 = FJ. | last6 = Trojanowski | first6 = JQ. | last7 = Molenaar | first7 = JC. | title = Differences in phosphorylation state of neurofilament proteins in ganglionic and aganglionic bowel segments of children with Hirschsprung's disease. | journal = J Pediatr Surg | volume = 27 | issue = 7 | pages = 815-9 | month = Jul | year = 1992 | doi = | PMID = 1640323 }}</ref> | Features:<ref name=pmid1640323>{{Cite journal | last1 = Luider | first1 = TM. | last2 = van Dommelen | first2 = MW. | last3 = Tibboel | first3 = D. | last4 = Meijers | first4 = JH. | last5 = Ten Kate | first5 = FJ. | last6 = Trojanowski | first6 = JQ. | last7 = Molenaar | first7 = JC. | title = Differences in phosphorylation state of neurofilament proteins in ganglionic and aganglionic bowel segments of children with Hirschsprung's disease. | journal = J Pediatr Surg | volume = 27 | issue = 7 | pages = 815-9 | month = Jul | year = 1992 | doi = | PMID = 1640323 }}</ref> | ||
*NF-M - highlight hypertrophic nerve fascicules | *NF-M (neurofilament middle) - highlight hypertrophic nerve fascicules | ||
*NF-H - highlight hypertrophic nerve fascicules. | *NF-H (neurofilament high) - highlight hypertrophic nerve fascicules. | ||
*Tau ~ highlights ganglion cells (which are absent in segments affected by Hirschsprung).<ref name=pmid8229560>{{Cite journal | last1 = Deguchi | first1 = E. | last2 = Iwai | first2 = N. | last3 = Goto | first3 = Y. | last4 = Yanagihara | first4 = J. | last5 = Fushiki | first5 = S. | title = An immunohistochemical study of neurofilament and microtubule-associated Tau protein in the enteric innervation in Hirschsprung's disease. | journal = J Pediatr Surg | volume = 28 | issue = 7 | pages = 886-90 | month = Jul | year = 1993 | doi = | PMID = 8229560 }}</ref> | *Tau ~ highlights ganglion cells (which are absent in segments affected by Hirschsprung).<ref name=pmid8229560>{{Cite journal | last1 = Deguchi | first1 = E. | last2 = Iwai | first2 = N. | last3 = Goto | first3 = Y. | last4 = Yanagihara | first4 = J. | last5 = Fushiki | first5 = S. | title = An immunohistochemical study of neurofilament and microtubule-associated Tau protein in the enteric innervation in Hirschsprung's disease. | journal = J Pediatr Surg | volume = 28 | issue = 7 | pages = 886-90 | month = Jul | year = 1993 | doi = | PMID = 8229560 }}</ref> | ||
**Nerve fibres +ve control. | **Nerve fibres +ve control. | ||