Difference between revisions of "Giant cells"
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| Line 11: | Line 11: | ||
| Type | | Type | ||
| Histology | | Histology | ||
| | | DDx | ||
| Other | | Other | ||
| Image | | Image | ||
| Line 17: | Line 17: | ||
| Touton giant cell | | Touton giant cell | ||
| nuclei form a ring around the cell periphery | | nuclei form a ring around the cell periphery | ||
| | | [[juvenile xanthogranuloma]], [[Erdheim-Chester disease]] | ||
| high lipid content lesions<ref>URL: [http://granuloma.homestead.com/giant_cells.html http://granuloma.homestead.com/giant_cells.html]. Accessed on: 7 February 2011.</ref> | | high lipid content lesions<ref>URL: [http://granuloma.homestead.com/giant_cells.html http://granuloma.homestead.com/giant_cells.html]. Accessed on: 7 February 2011.</ref> | ||
| [http://commons.wikimedia.org/wiki/File:Juvenile_xanthogranuloma_-_very_high_mag.jpg JXG (WC)] | | [http://commons.wikimedia.org/wiki/File:Juvenile_xanthogranuloma_-_very_high_mag.jpg JXG (WC)] | ||
| Line 23: | Line 23: | ||
| Epithelioid type | | Epithelioid type | ||
| scattered nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | | scattered nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | ||
| | | drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic | ||
| | | [[granuloma|granulomatous inflammation]] | ||
| [http://commons.wikimedia.org/wiki/File:Crohn%27s_disease_-_colon_-_very_high_mag.jpg Granuloma (WC)] | | [http://commons.wikimedia.org/wiki/File:Crohn%27s_disease_-_colon_-_very_high_mag.jpg Granuloma (WC)] | ||
|- | |- | ||
| Line 35: | Line 35: | ||
| Osteoclast-like giant cells | | Osteoclast-like giant cells | ||
| round nuclei | | round nuclei | ||
| | | osteoclasts, others | ||
| [[AKA]] osteoclast-type giant cells | | [[AKA]] osteoclast-type giant cells | ||
| [http://www.webpathology.com/image.asp?n=20&Case=58 (webpathology.com)] | | [http://www.webpathology.com/image.asp?n=20&Case=58 (webpathology.com)] | ||
Revision as of 17:54, 25 March 2012
Giant cells are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality.
Giant cell types
List:
- Touton giant cell.
- Osteoclast-like giant cell.
- Foreign body type giant cell.
Table
| Type | Histology | DDx | Other | Image |
| Touton giant cell | nuclei form a ring around the cell periphery | juvenile xanthogranuloma, Erdheim-Chester disease | high lipid content lesions[1] | JXG (WC) |
| Epithelioid type | scattered nuclei[2] | drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic | granulomatous inflammation | Granuloma (WC) |
| Langhans giant cell | peripheral eccentric nuclei[2] | ? | not to be confused with Langerhans cells | LGC (WC) |
| Osteoclast-like giant cells | round nuclei | osteoclasts, others | AKA osteoclast-type giant cells | (webpathology.com) |
See also
- Basics.
- Giant cell lesions - includes a DDx of lesions with giant cells.
- Histiocytoses.
References
- ↑ URL: http://granuloma.homestead.com/giant_cells.html. Accessed on: 7 February 2011.
- ↑ 2.0 2.1 Borley, Neil R.; Warren, Bryan F. (2007). Instant Pathology (1st ed.). Wiley-Blackwell. pp. 7. ISBN 978-1405132909.