Neurodegenerative diseases: Difference between revisions
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m →Common diseases: w |
m →Microscopic: w |
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*Loss of pigmented (catecholaminergic) neurons in the substantia nigra and locus ceruleus. | *Loss of pigmented (catecholaminergic) neurons in the substantia nigra and locus ceruleus. | ||
*Gliosis - due to neuron loss. | *Gliosis - due to neuron loss. | ||
*Lewy bodies (in remaining neurons) - '''key feature'''. | *[[Lewy bodies]] (in remaining neurons) - '''key feature'''. | ||
**Eosinophilic cytoplasmic inclusion with "dense" (darker) core and pale (surrounding) halo. | **Eosinophilic cytoplasmic inclusion with "dense" (darker) core and pale (surrounding) halo. | ||
***Consist of filaments composed of alpha-synuclein. | ***Consist of filaments composed of alpha-synuclein. | ||