Difference between revisions of "Kimura disease"
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==IHC== | ==IHC== | ||
*Used to rule-out a clonal population. | *Used to rule-out a clonal population, i.e. [[lymphoma]]. | ||
==See also== | ==See also== | ||
Revision as of 17:10, 19 December 2011
Kimura disease is a rare disease with abundant eosinophils. It may show-up in a lymph node specimen.
General
- AKA eosinophilic lymphogranuloma, Kimura disease.
- Chronic inflammatory disorder - suspected to be infectious.
Clinical:
- Usually neck, periauricular.
- Peripheral blood eosinophilia.
- Increased blood IgE.
Epidemiology
- Males > females.
- Young.
- Asian.
Microscopic
Features:[1]
- Angiolymphoid proliferation.
- Thick walled blood vessels with (plump) hobnail endothelial cells.[2]
- Eosinophils - abundant - key feature.
DDx:
- Drug reaction.
- Parasitic infection.
Notes:
- In a lymph node... it may be signed-out as reactive lymphadenitis with follicular hyperplasia and prominent eosinophils, see comment.
- Abundant eosinophils: consider Langerhans cell histiocytosis.
Images:
- Kimura disease - very high mag. (WC).
- Kimura disease - high mag. (WC).
- Kimura disease - intermed. mag. (WC).
IHC
- Used to rule-out a clonal population, i.e. lymphoma.
See also
References
- ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 190. ISBN 978-0781775960.
- ↑ URL: http://emedicine.medscape.com/article/1098777-diagnosis. Accessed on: 8 August 2010.