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Difference between revisions of "Soft tissue lesions"
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update WMSP
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==WHO classification of soft tissue lesions/tumours== | ==WHO classification of soft tissue lesions/tumours== | ||
===Morphologic grouping<ref>WMSP | ===Morphologic grouping<ref name=Ref_WMSP601-3>{{Ref WMSP|601-3}}</ref>=== | ||
#Adipocytic tumours. | #Adipocytic tumours. | ||
#Fibroblastic/myofibroblastic tumours. | #Fibroblastic/myofibroblastic tumours. | ||
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#Tumours of uncertain differentiation. | #Tumours of uncertain differentiation. | ||
===Biologic potential grouping<ref>WMSP | ===Biologic potential grouping<ref>{{Ref WMSP|598-604}}</ref>=== | ||
#Benign. | #Benign. | ||
#Intermediate (locally aggressive). | #Intermediate (locally aggressive). | ||
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==Hibernoma== | ==Hibernoma== | ||
===General=== | ===General=== | ||
*Consists of ''brown fat'' (present in the infants to generate heat).<ref>WMSP | *Consists of ''brown fat'' (present in the infants to generate heat).<ref name=Ref_WMSP605>{{Ref WMSP|605}}</ref> | ||
*Benign. | *Benign. | ||
*Usually asymptomatic.<ref name=pmid19131775>{{cite journal |author=Ahmed SA, Schuller I |title=Pediatric hibernoma: a case review |journal=J. Pediatr. Hematol. Oncol. |volume=30 |issue=12 |pages=900–1 |year=2008 |month=December |pmid=19131775 |doi=10.1097/MPH.0b013e318184e6dd |url=}}</ref> | *Usually asymptomatic.<ref name=pmid19131775>{{cite journal |author=Ahmed SA, Schuller I |title=Pediatric hibernoma: a case review |journal=J. Pediatr. Hematol. Oncol. |volume=30 |issue=12 |pages=900–1 |year=2008 |month=December |pmid=19131775 |doi=10.1097/MPH.0b013e318184e6dd |url=}}</ref> | ||
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===IHC=== | ===IHC=== | ||
Features:<ref>WMSP | Features:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref><ref name=enzinger/> | ||
*Vimentin +ve (usually). | *Vimentin +ve (usually). | ||
*Desmin -ve (typical). | *Desmin -ve (typical). | ||
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====Grading==== | ====Grading==== | ||
Features:<ref>WMSP | Features:<ref name=Ref_WMSP643>{{Ref WMSP|643}}</ref> | ||
*Grade I: moderate cellularity +/- binucleated cells. | *Grade I: moderate cellularity +/- binucleated cells. | ||
*Grade III: nuclear pleomorphism, mitoses common. | *Grade III: nuclear pleomorphism, mitoses common. | ||
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==Synovial sarcoma== | ==Synovial sarcoma== | ||
===General=== | ===General=== | ||
*Does not arise from cartilage.<ref>WMSP | *Does not arise from cartilage.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
*Young adults or adolescents. | *Young adults or adolescents. | ||
===Microscopic=== | ===Microscopic=== | ||
Comes in three flavours:<ref>WMSP | Comes in three flavours:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref><ref>{{cite journal |author=Schaal CH, Navarro FC, Moraes Neto FA |title=Primary renal sarcoma with morphologic and immunohistochemical aspects compatible with synovial sarcoma |journal=Int Braz J Urol |volume=30 |issue=3 |pages=210–3 |year=2004 |pmid=15689250 |doi= |url=http://www.brazjurol.com.br/may_june_2004/Schaal_ing_210_213.htm}}</ref> | ||
#Spindle cell sarcoma with features of hemangiopericytoma, i.e. staghorn vessels. | #Spindle cell sarcoma with features of hemangiopericytoma, i.e. staghorn vessels. | ||
#Biphasic synovial sarcoma: | #Biphasic synovial sarcoma: | ||
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===IHC=== | ===IHC=== | ||
Features:<ref>WMSP | Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
*Vimentin +ve + cytokeratin and/or EMA +ve. | *Vimentin +ve + cytokeratin and/or EMA +ve. | ||
*CD99 +ve. | *CD99 +ve. | ||