Account-creators
1,040
edits
Difference between revisions of "Gene fusion"
Jump to navigation
Jump to search
no edit summary
Jensflorian (talk | contribs) m (history) |
Jensflorian (talk | contribs) |
||
| Line 9: | Line 9: | ||
First fusion was described as BCR-ABL1 fusion in [[CML]]. Subsequently [[Imatinib]] was the first inhibitor targeting CML with BCR-ABL1 fusion. | First fusion was described as BCR-ABL1 fusion in [[CML]]. Subsequently [[Imatinib]] was the first inhibitor targeting CML with BCR-ABL1 fusion. | ||
==Methodology== | |||
Gene fusions can be detected by: | |||
* [[RT-PCR]] (fusion partners need to be known). | |||
* [[FISH]]. | |||
* RNA-Sequencing. | |||
* Whole Genome sequencing (WGS) (Comprehensive and unbiased, but short read length). | |||
* [[Immunohistochemistry]] (not suitable/available for all fusions). | |||