Account-creators
1,040
edits
Difference between revisions of "Lhermitte-Duclos disease"
Jump to navigation
Jump to search
Lhermitte-Duclos disease (view source)
Revision as of 09:54, 13 October 2015
, 09:54, 13 October 2015update +pics
Jensflorian (talk | contribs) (update +pics) |
|||
| Line 6: | Line 6: | ||
*[[Cerebellum|Cerebellar]] lesion. | *[[Cerebellum|Cerebellar]] lesion. | ||
*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM|158350}}</ref> | *May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM|158350}}</ref> | ||
*Rarely bilateral.<ref>{{Cite journal | last1 = Bozbuga | first1 = M. | last2 = Gulec | first2 = I. | last3 = Suslu | first3 = HT. | last4 = Bayindir | first4 = C. | title = Bilateral Lhermitte-Duclos disease. | journal = Neurol India | volume = 58 | issue = 2 | pages = 309-11 | month = | year = | doi = 10.4103/0028-3886.63799 | PMID = 20508358 }}</ref> | |||
*ICD-O code: 9493/0 | |||
==Microscopic== | ==Microscopic== | ||
| Line 13: | Line 15: | ||
*Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''. | *Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''. | ||
*+/-Microcalcifications. | *+/-Microcalcifications. | ||
==IHC== | |||
*Synapto+ve. | |||
*Calbindin+ve. | |||
*PTEN-ve. | |||
*MIB-1 almost absent. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
File:Dysplastic cerebellar gangliocytoma.jpg | LDD in cerebellar cross section (AFIP) | |||
Image:Dysplastic gangliocytoma lhermitte duclos.jpg | LDD. (WC/Jensflorian) | Image:Dysplastic gangliocytoma lhermitte duclos.jpg | LDD. (WC/Jensflorian) | ||
File:Lhermitte Duclos Luxol.jpg | LDD, Luxol fast blue stain. (WC/Sbrandner) | |||
File:Lhermitte Duclos Calbindin.jpg | LDD, Calbindin. (WC/Sbrandner) | |||
</gallery> | </gallery> | ||
www: | www: | ||
*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)]. | ||
==Molecular== | |||
*PTEN inactivation. <ref>{{Cite journal | last1 = Chen | first1 = XY. | last2 = Lu | first2 = F. | last3 = Wang | first3 = YM. | last4 = Yang | first4 = Y. | last5 = Wei | first5 = GQ. | last6 = Wu | first6 = D. | last7 = Wang | first7 = LF. | last8 = Wu | first8 = YM. | title = PTEN inactivation by germline/somatic c.950_953delTACT mutation in patients with Lhermitte-Duclos disease manifesting progressive phenotypes. | journal = Clin Genet | volume = 86 | issue = 4 | pages = 349-54 | month = Oct | year = 2014 | doi = 10.1111/cge.12282 | PMID = 24102544 }}</ref> | |||
**Mosaic forms reported.<ref>{{Cite journal | last1 = Pritchard | first1 = CC. | last2 = Smith | first2 = C. | last3 = Marushchak | first3 = T. | last4 = Koehler | first4 = K. | last5 = Holmes | first5 = H. | last6 = Raskind | first6 = W. | last7 = Walsh | first7 = T. | last8 = Bennett | first8 = RL. | title = A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing. | journal = Genet Med | volume = 15 | issue = 12 | pages = 1004-7 | month = Dec | year = 2013 | doi = 10.1038/gim.2013.51 | PMID = 23619277 }}</ref> | |||
==DDx:== | |||
(Usually on imaging): | |||
*Arachnoid vascular malformation <ref>{{Cite journal | last1 = Huang | first1 = S. | last2 = Zhang | first2 = G. | last3 = Zhang | first3 = J. | title = Similar MR imaging characteristics but different pathological changes: a misdiagnosis for Lhermitte-Duclos disease and review of the literature. | journal = Int J Clin Exp Pathol | volume = 8 | issue = 6 | pages = 7583-7 | month = | year = 2015 | doi = | PMID = 26261673 }}</ref> | |||
*Cerebellar [[Pleomorphic xanthoastrocytoma]]<ref>{{Cite journal | last1 = Takei | first1 = H. | last2 = Rouah | first2 = E. | last3 = Bhattacharjee | first3 = MB. | title = Cerebellar pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1: a case report and literature review. | journal = Int J Clin Exp Pathol | volume = 8 | issue = 6 | pages = 7570-4 | month = | year = 2015 | doi = | PMID = 26261671 }}</ref> | |||
*[[Medulloblastoma]]<ref>{{Cite journal | last1 = Douglas-Akinwande | first1 = AC. | last2 = Payner | first2 = TD. | last3 = Hattab | first3 = EM. | title = Medulloblastoma mimicking Lhermitte-Duclos disease on MRI and CT. | journal = Clin Neurol Neurosurg | volume = 111 | issue = 6 | pages = 536-9 | month = Jul | year = 2009 | doi = 10.1016/j.clineuro.2009.01.008 | PMID = 19233547 }}</ref> | |||
==See also== | ==See also== | ||
| Line 29: | Line 52: | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:WHO grade I tumours]] | |||