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Difference between revisions of "Neuromuscular pathology"
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+ LGMD + Nemaline myopathy
Jensflorian (talk | contribs) (+granulomatous myositis & others....) |
Jensflorian (talk | contribs) (+ LGMD + Nemaline myopathy) |
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Notes: | Notes: | ||
*Can be demonstrated with [[IHC]]. | *Can be demonstrated with [[IHC]]. | ||
===DDx=== | ===DDx=== | ||
| Line 434: | Line 432: | ||
*Congenital MD (CMD). | *Congenital MD (CMD). | ||
*Inflammatory myopathies. | *Inflammatory myopathies. | ||
<gallery> | |||
File:LGMD2D alpha sarcoglycan.jpg | Loss of alpha sarcocglycan in LGMD2D (WC). | |||
</gallery> | |||
==Mitochondrial disorders== | ==Mitochondrial disorders== | ||
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Image:Dermatomyositis_-_intermed_mag.jpg | Dermatomyositis - intermed. mag. (WC) | Image:Dermatomyositis_-_intermed_mag.jpg | Dermatomyositis - intermed. mag. (WC) | ||
Image:Dermatomyositis_-_high_mag.jpg | Dermatomyositis - high mag. (WC) | Image:Dermatomyositis_-_high_mag.jpg | Dermatomyositis - high mag. (WC) | ||
File:Dermatomyositis HE x40.jpg | Dermatomyositis - low mag. (WC) | |||
File:Dermatomyositis c5b9.jpg | C5b9 complex deposits in dermatomyositis (WC) | |||
</gallery> | </gallery> | ||
| Line 514: | Line 519: | ||
Images: | Images: | ||
*[http://moon.ouhsc.edu/kfung/jty1/Com/Com310-1-Diss.htm Tubulorecticular inclusions (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/Com/Com310-1-Diss.htm Tubulorecticular inclusions (ouhsc.edu)]. | ||
==Inclusion body myositis== | ==Inclusion body myositis== | ||
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===EM=== | ===EM=== | ||
*Inclusion bodies - tubulovescicular material.<ref>URL: [http://neuromuscular.wustl.edu/pathol/ibm.htm http://neuromuscular.wustl.edu/pathol/ibm.htm]. Accessed on: 3 November 2010.</ref> | *Inclusion bodies - tubulovescicular material.<ref>URL: [http://neuromuscular.wustl.edu/pathol/ibm.htm http://neuromuscular.wustl.edu/pathol/ibm.htm]. Accessed on: 3 November 2010.</ref> | ||
<gallery> | |||
File:IBM rimmed vacuoles HE x200.jpg | Rimmed vacuoles in inclusion body myositis (HE). | |||
</gallery> | |||
==Polymyositis== | ==Polymyositis== | ||
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**Perimysial - B cells. | **Perimysial - B cells. | ||
| Line 614: | Line 619: | ||
*A type of congenital myopathy. | *A type of congenital myopathy. | ||
*Paediatric thingy. | *Paediatric thingy. | ||
*Rods are seen in trichrome stain | |||
<gallery> | |||
File:Biopsy nemaline myopathy gomori.jpg | Nemaline rods (Trichrom Gomöri). | |||
</gallery> | |||
==Centronuclear myopathy== | ==Centronuclear myopathy== | ||