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→Features that assist one in finding granulomas
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===Features that assist one in finding granulomas=== | ===Features that assist one in finding granulomas=== | ||
#Collection of cells that have abundant bubbly cytoplasm - '''most useful feature'''. | |||
#*Image: [http://commons.wikimedia.org/wiki/File:Granuloma_20x.jpg Granulomas showing abundant bubbly cytoplasm (WC)]. | |||
#'''Multinucleated [[giant cells]]''' - these are easy to identify if you've seen some before. | |||
#*Individual/singular multinucleated giant cells are not diagnostic of a granuloma... but should raise one's suspicion of one being present. | |||
#*Image: [http://commons.wikimedia.org/wiki/File:Asteroid_body_intermed_mag.jpg Granulomas with multinucleated giant cells in sarcoidosis (WC)]. | |||
#Necrosis - too much pink (on H&E stained sections). | |||
#*Image: [http://commons.wikimedia.org/wiki/File:Necrogran10x.jpg Granuloma with necrosis (WC)]. | |||
Notes: | |||
*Small round collection of lymphocytes - without a capsule (as seen in lymph nodes). | *Small round collection of lymphocytes - without a capsule (as seen in lymph nodes). | ||
**If there are no macrophages... it's a ''lymphoid nodule''. | **If there are no macrophages... it's a ''lymphoid nodule''. | ||
====As a list==== | |||
Features:<ref>GS. 26 January 2010.</ref> | |||
#Foamy/bubbly cytoplasm, abundant - '''low power'''. | |||
#Epithelioid morphology - cell borders ''near'' indistinct - '''key feature'''. | |||
#"Footprint" pattern nuclei/bean-shaped nuclei - '''key feature'''. | |||
#*Macrophages usu. have an ovoid nucleus. | |||
#+/-Nucleoli, small. | |||
#+/-Fibrosis. | |||
#+/-Pallisading at edge. | |||
===Classification of granuloma=== | ===Classification of granuloma=== | ||