Difference between revisions of "Case 113"

 

{{hidden|Diagnosis|<center>PILOMYXOID ASTROCYTOMA GRADE II WHO WITH KIAA1549(Exon15)-BRAF(Exon9) FUSION</center>

Comment: Pilomyxoid astrocytomas are a variant of [[pilocytic astrocytoma]] and share the same genetic abberations such as KIAA1549-BRAF fusions as seen in the current case. They usually lack the typical compact areas with rosenthal fibers seen in pilocytic astrocytomas. The tumors have been designated as WHO grade II tumours in the 2007 WHO classification, because of their tendency to recur more often. <ref>{{Cite journal  | last1 = Brat | first1 = DJ. | last2 = Scheithauer | first2 = BW. | last3 = Fuller | first3 = GN. | last4 = Tihan | first4 = T. | title = Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. | journal = Brain Pathol | volume = 17 | issue = 3 | pages = 319-24 | month = Jul | year = 2007 | doi = 10.1111/j.1750-3639.2007.00082.x | PMID = 17598825 }}</ref> A hypothalamic/chiasmatic location itself is a adverse prognostic factor. <ref>{{Cite journal  | last1 = Colin | first1 = C. | last2 = Padovani | first2 = L. | last3 = Chappé | first3 = C. | last4 = Mercurio | first4 = S. | last5 = Scavarda | first5 = D. | last6 = Loundou | first6 = A. | last7 = Frassineti | first7 = F. | last8 = André | first8 = N. | last9 = Bouvier | first9 = C. | title = Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution. | journal = Neuropathol Appl Neurobiol | volume = 39 | issue = 6 | pages = 693-705 | month = Oct | year = 2013 | doi = 10.1111/nan.12013 | PMID = 23278243 }}</ref>