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Difference between revisions of "Sertoli-Leydig cell tumour"
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→Microscopic
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* Sertoli ''or'' Leydig cells.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | |||
** Leydig cells: | |||
***Polygonal pink cells | |||
*** Abundant solid or somewhat granular eosinophilic cytoplasm. | |||
*** Round nuclei with fine chromatin and a small or indistinct [[nucleolus]]. | |||
*** Often in small clusters ~ 5-25 cells/cluster. | |||
** Sertoli cells: | |||
*** Pale/clear vacuolated cytoplasm. | |||
*** Irregular nuclei with irregular/vacuolated-appearing chromatin. | |||
*** Architecture: tubules, cords or sheets. | |||
***Mitotic activity may be much lower than expected for the degree of atypia (in comparison to adenocarcinoma). | |||
*Growth Patterns: | *Growth Patterns: | ||
**Well-differentiated. | **Well-differentiated. | ||
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**Retiform. | **Retiform. | ||
***Tumour resembles rete testis/ovary with blunt papillae and irregular cleft-like spaces. | ***Tumour resembles rete testis/ovary with blunt papillae and irregular cleft-like spaces. | ||
*+/-Stromal edema may be prominent | |||
*+/-Sarcomatous features (mucinous glands, bone, cartilage). | |||
DDx: | DDx: | ||