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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 16:19, 23 November 2010
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==IHC== | ==IHC== | ||
===Alpha-synuclein=== | |||
Look for: | |||
*Lewy bodies (seen in Parkinson's d., Dementia with Lewy bodies) = round cytoplasmic eosinophilic body +/- pale halo. | |||
===Tau=== | ===Tau=== | ||
*AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | *AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | ||
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====Microscopic==== | ====Microscopic==== | ||
*p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | *p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | ||
Look for: | |||
*Lewy bodies. (???) | |||
==Clinical perspective (becoming obsolete)== | ==Clinical perspective (becoming obsolete)== | ||