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Difference between revisions of "Prostate cancer"
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→Intraductal carcinoma of the prostate: add criteria
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(→Intraductal carcinoma of the prostate: add criteria) |
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===Microscopic=== | ===Microscopic=== | ||
====Major criteria==== | |||
Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref> | |||
**Two cell populations: | #Glands 2x normal (peripheral zone) glands. | ||
* | #Basal cell present (proven by IHC). | ||
* | #"Cytologically malignant cells" = nuclear hyperchromasia, nuclear enlargement, nucleoli. | ||
#Fills the lumen ("expansile") but does not have to be "solid". | |||
#*Solid = no spaces between the cells. | |||
Additional (major) criterium:<ref name=pmid22692290/> | |||
*Comedo[[necrosis]]. | |||
====Minor criteria==== | |||
Minor criteria:<ref name=pmid22692290/> | |||
#Branching of ducts at right angles. | |||
#Rounded/smooth gland outlines. | |||
#Two cell populations: | |||
#*Enlarge nuclei with hyperchromasia and nucleoli (malignant) = peripheral. | |||
#*Smaller nuclei, no nucleoli (benign) = central. | |||
DDx: | DDx: | ||
*[[ | *[[High-grade prostatic intraepithelial neoplasia]] (HGPIN). | ||
===IHC=== | ===IHC=== | ||
Features - basal cells present: | Features - basal cells present: | ||
* | *CK34betaE12 +ve. | ||
*p63 +ve. | |||
=Unusual forms of prostate cancer= | =Unusual forms of prostate cancer= | ||