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Difference between revisions of "Malignant melanoma"
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→Margin assessment: tweak
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====Margin assessment==== | ====Margin assessment==== | ||
{{Main|Surgical margin}} | {{Main|Surgical margin}} | ||
Margin assessment is notoriously difficult as there are numerous mimics of melanoma in situ:<ref name=pmid21549242>{{Cite journal | last1 = Trotter | first1 = MJ. | title = Melanoma margin assessment. | journal = Clin Lab Med | volume = 31 | issue = 2 | pages = 289-300 | month = Jun | year = 2011 | doi = 10.1016/j.cll.2011.03.006 | PMID = 21549242 }}</ref> | =====General===== | ||
*Melanocytic hyperplasia (considered to be on a continuum with melanoma) may be due to: | *Adequate distance dependent on tumour stage - ''see [[Surgical_margins#Adequate_margins_by_tumour|surgical margin]]'' article. | ||
**Light exposure. | *Margin assessment is notoriously difficult as there are numerous mimics of melanoma in situ:<ref name=pmid21549242>{{Cite journal | last1 = Trotter | first1 = MJ. | title = Melanoma margin assessment. | journal = Clin Lab Med | volume = 31 | issue = 2 | pages = 289-300 | month = Jun | year = 2011 | doi = 10.1016/j.cll.2011.03.006 | PMID = 21549242 }}</ref> | ||
**Peritumoral-effect. | *#Melanocytic hyperplasia (considered to be on a continuum with melanoma) may be due to: | ||
**Previous biopsy. | *#*Light exposure. | ||
*Solar lentigo. | *#*Peritumoral-effect. | ||
*Lichenoid | *#*Previous biopsy. | ||
*#Solar lentigo. | |||
*#Lichenoid reactions. | |||
=====Microscopic===== | |||
Features of [[MIS]]:<ref name=pmid21549242/> | Features of [[MIS]]:<ref name=pmid21549242/> | ||
#Pagetoid spread of melanocytes. | #Pagetoid spread of melanocytes. | ||
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#Adenxal involvement. | #Adenxal involvement. | ||
Lame mnemonic ''MARGIN'': | |||
*'''M'''arked cytologic atypia. | |||
*'''A'''dnexal involvement. | |||
*'''R'''ow of melanocytes. | |||
*'''G'''ravity defying melanocytes (Pagetoid spread). | |||
*'''I'''ncreased basal melanocytes. | |||
*'''N'''ests of melanocytes. | |||
====Subtypes==== | ====Subtypes==== | ||