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Difference between revisions of "Liver transplantation pathology"
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Liver transplantation pathology (view source)
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'''Liver transplantation pathology''' is a niche within a niche. It deals with question: "Is it rejection or something else?". | '''Liver transplantation pathology''' is a niche within a niche. It deals with question: "Is it rejection or something else?". | ||
==Donor liver suitability== | |||
Donor livers are assessed using [[frozen section]]: | |||
*Donor liver ''macrovesicular [[steatosis]]'' should ''not'' exceed 30% - as it associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal | last1 = Heller | first1 = B. | last2 = Peters | first2 = S. | title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. | journal = J Clin Med Res | volume = 3 | issue = 4 | pages = 191-4 | month = Jul | year = 2011 | doi = 10.4021/jocmr629w | PMID = 22121403 }}</ref> | |||
Note: | |||
*Microvesicular steatosis does ''not'' appear to affect graft function.<ref name=pmid11070113>{{Cite journal | last1 = Crowley | first1 = H. | last2 = Lewis | first2 = WD. | last3 = Gordon | first3 = F. | last4 = Jenkins | first4 = R. | last5 = Khettry | first5 = U. | title = Steatosis in donor and transplant liver biopsies. | journal = Hum Pathol | volume = 31 | issue = 10 | pages = 1209-13 | month = Oct | year = 2000 | doi = 10.1053/hupa.2000.18473 | PMID = 11070113 }}</ref> | |||
==Rejection== | ==Rejection== | ||