Difference between revisions of "Medical kidney diseases"
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=Mixed nephrotic and nephritic= | =Mixed nephrotic and nephritic= | ||
==IgA nephropathy== | ==IgA nephropathy== | ||
*[[AKA]] Berger disease. | |||
===General=== | ===General=== | ||
*More common in Asians. | *More common in Asians. | ||
*Associated with an increased incidence of [[Celiac disease]].<ref name=pmid19332868>{{Cite journal | last1 = Smerud | first1 = HK. | last2 = Fellström | first2 = B. | last3 = Hällgren | first3 = R. | last4 = Osagie | first4 = S. | last5 = Venge | first5 = P. | last6 = Kristjánsson | first6 = G. | title = Gluten sensitivity in patients with IgA nephropathy. | journal = Nephrol Dial Transplant | volume = 24 | issue = 8 | pages = 2476-81 | month = Aug | year = 2009 | doi = 10.1093/ndt/gfp133 | PMID = 19332868 }}</ref> | *Associated with an increased incidence of [[Celiac disease]].<ref name=pmid19332868>{{Cite journal | last1 = Smerud | first1 = HK. | last2 = Fellström | first2 = B. | last3 = Hällgren | first3 = R. | last4 = Osagie | first4 = S. | last5 = Venge | first5 = P. | last6 = Kristjánsson | first6 = G. | title = Gluten sensitivity in patients with IgA nephropathy. | journal = Nephrol Dial Transplant | volume = 24 | issue = 8 | pages = 2476-81 | month = Aug | year = 2009 | doi = 10.1093/ndt/gfp133 | PMID = 19332868 }}</ref> | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Mesangial hypercellularity - may be only light microscopy finding. | *Variable: | ||
**Mesangial hypercellularity - may be only light microscopy finding. | |||
Note: | |||
*Diagnosis based on immunofluorescence (IgA+). | *Diagnosis based on immunofluorescence (IgA+). | ||
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====Scoring==== | ====Scoring==== | ||
IgA nephropathy can be scored using an assessment of '''m'''esangial proliferation, '''e'''ndocapillary proliferation, glomerulo'''s'''clerosis and '''t'''ubular atrophy and interstitial fibrosis (abbreviated ''MEST'').<ref>{{Cite journal | last1 = Coppo | first1 = R. | last2 = Cattran | first2 = D. | last3 = Roberts Ian | first3 = SD. | last4 = Troyanov | first4 = S. | last5 = Camilla | first5 = R. | last6 = Cook | first6 = T. | last7 = Feehally | first7 = J. | title = The new Oxford Clinico-Pathological Classification of IgA nephropathy. | journal = Prilozi | volume = 31 | issue = 1 | pages = 241-8 | month = Jul | year = 2010 | doi = | PMID = 20693944 }}</ref> | IgA nephropathy can be scored using an assessment of '''m'''esangial proliferation, '''e'''ndocapillary proliferation, glomerulo'''s'''clerosis and '''t'''ubular atrophy and interstitial fibrosis (abbreviated ''MEST'').<ref>{{Cite journal | last1 = Coppo | first1 = R. | last2 = Cattran | first2 = D. | last3 = Roberts Ian | first3 = SD. | last4 = Troyanov | first4 = S. | last5 = Camilla | first5 = R. | last6 = Cook | first6 = T. | last7 = Feehally | first7 = J. | title = The new Oxford Clinico-Pathological Classification of IgA nephropathy. | journal = Prilozi | volume = 31 | issue = 1 | pages = 241-8 | month = Jul | year = 2010 | doi = | PMID = 20693944 }}</ref> | ||
===IF=== | |||
*IgA +ve -- branching pattern. | |||
===EM=== | |||
*Mesangial deposits. | |||
**These are electron dense, ergo dark on EM images. | |||
==Membranoproliferative glomerulonephritis== | ==Membranoproliferative glomerulonephritis== | ||