Difference between revisions of "Dermatologic neoplasms"

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(merge two MCCs)
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=Less common malignant=
=Less common malignant=
==Merkel cell carcinoma==
*Abbreviated ''MCC''.
===General===
*Aggressive.
*Rare.
*Increased risk in the immunodeficient.
*Most caused by ''Merkel cell polyomavirus''.<ref name=pmid18202256>{{Cite journal  | last1 = Feng | first1 = H. | last2 = Shuda | first2 = M. | last3 = Chang | first3 = Y. | last4 = Moore | first4 = PS. | title = Clonal integration of a polyomavirus in human Merkel cell carcinoma. | journal = Science | volume = 319 | issue = 5866 | pages = 1096-100 | month = Feb | year = 2008 | doi = 10.1126/science.1152586 | PMID = 18202256 }}</ref>
===Microscopic===
Features:
*Neuroendocrine nuclear features - round nucleus, no nucleolus, stippled chromatin - '''key feature'''.
*Typically medium size cells ~3x resting lymphocyte.
**May be small or large.
*Arranged in a nested pattern or sheets.
*Scant cytoplasm.
*Abundant mitoses.
*+/-Nuclear moulding.
DDx:
*[[Basal cell carcinoma]] - no stippled chromatin, less mitoses active.
*Cutaneous [[Ewing sarcoma]] - sorted-out with immunostains.
*[[Lymphoma]].
Images:
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ng12hist.htm MCC (bccancer.bc.ca)].
*[http://www.joplink.net/prev/200403/07.html MCC (joplink.net)].
===IHC===
Features:
*CK7 -ve.
*CK20 +ve.
*CAM5.2 +ve (dot-like pattern).
Others:
*TTF-1 -ve.
==Dermatofibrosarcoma protuberans==
==Dermatofibrosarcoma protuberans==
*Abbreviated ''DFSP''.
*Abbreviated ''DFSP''.
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==Merkel cell carcinoma==
==Merkel cell carcinoma==
*Abbreviated ''MCC''.
===General===
*Aggressive.
*Rare.
*Increased risk in the immunodeficient.
*Most caused by ''Merkel cell polyomavirus''.<ref name=pmid18202256>{{Cite journal  | last1 = Feng | first1 = H. | last2 = Shuda | first2 = M. | last3 = Chang | first3 = Y. | last4 = Moore | first4 = PS. | title = Clonal integration of a polyomavirus in human Merkel cell carcinoma. | journal = Science | volume = 319 | issue = 5866 | pages = 1096-100 | month = Feb | year = 2008 | doi = 10.1126/science.1152586 | PMID = 18202256 }}</ref>
===General===
===General===
Features:<ref name=pmid20418670>{{Cite journal  | last1 = Calder | first1 = KB. | last2 = Smoller | first2 = BR. | title = New insights into merkel cell carcinoma. | journal = Adv Anat Pathol | volume = 17 | issue = 3 | pages = 155-61 | month = May | year = 2010 | doi = 10.1097/PAP.0b013e3181d97836 | PMID = 20418670 }}</ref>
Features:<ref name=pmid20418670>{{Cite journal  | last1 = Calder | first1 = KB. | last2 = Smoller | first2 = BR. | title = New insights into merkel cell carcinoma. | journal = Adv Anat Pathol | volume = 17 | issue = 3 | pages = 155-61 | month = May | year = 2010 | doi = 10.1097/PAP.0b013e3181d97836 | PMID = 20418670 }}</ref>
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===Microscopic===
===Microscopic===
Features:<ref name=Ref_WMSP491>{{Ref WMSP|491}}</ref>
Features:<ref name=Ref_WMSP491>{{Ref WMSP|491}}</ref>
*Nests or sheets or trabeculae.
*Neuroendocrine nuclear features - round nucleus, small nucleoli/no nucleolus, stippled chromatin - '''key feature'''.
*Typically medium size cells ~3x resting lymphocyte.
**May be small or large.
*Architecture: nests, sheets or trabeculae.
*Scant cytoplasm.
*Scant cytoplasm.
*Nuclear moulding.
*Abundant mitoses.
*Multiple small nucleoli.
*+/-Nuclear moulding.
*Usually mitotically active.
 
DDx:
*[[Basal cell carcinoma]] - no stippled chromatin, less mitoses active.
*Cutaneous [[Ewing sarcoma]] - sorted-out with immunostains.
*[[Lymphoma]].


Image:
Images:
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ng12hist.htm MCC (bccancer.bc.ca)].
*[http://www.joplink.net/prev/200403/07.html MCC (joplink.net)].
*[http://www.ispub.com/ispub/ijd/volume_5_number_2_8/concurrent_merkel_cell_carcinoma_and_bowen_s_disease_of_the_thigh/bowen-fig3.jpg Merkel cell carcinoma (ispub.com)].
*[http://www.ispub.com/ispub/ijd/volume_5_number_2_8/concurrent_merkel_cell_carcinoma_and_bowen_s_disease_of_the_thigh/bowen-fig3.jpg Merkel cell carcinoma (ispub.com)].
*[http://commons.wikimedia.org/wiki/File:Merkelcellcarcinoma_Tag.jpg Merkel cell carcinoma - nested pattern (WC)].
*[http://commons.wikimedia.org/wiki/File:Merkelcellcarcinoma_Tag.jpg Merkel cell carcinoma - nested pattern (WC)].


===IHC===
===IHC===
*CK7 -ve, CK20 +ve
Features:
*CK7 -ve.
*CK20 +ve.
*CAM5.2 +ve (dot-like pattern).
 
Others:
*TTF-1 -ve.


==Eccrine carcinoma==
==Eccrine carcinoma==
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