Difference between revisions of "Dermatologic neoplasms"
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(→Malignant: +merkel cell) |
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=Malignant= | =Malignant= | ||
==Merkel cell carcinoma== | |||
*Abbreviated ''MCC''. | |||
===General=== | |||
*Aggressive. | |||
*Rare. | |||
*Increased risk in the immunodeficient. | |||
*Most caused by ''Merkel cell polyomavirus''.<ref name=pmid18202256>{{Cite journal | last1 = Feng | first1 = H. | last2 = Shuda | first2 = M. | last3 = Chang | first3 = Y. | last4 = Moore | first4 = PS. | title = Clonal integration of a polyomavirus in human Merkel cell carcinoma. | journal = Science | volume = 319 | issue = 5866 | pages = 1096-100 | month = Feb | year = 2008 | doi = 10.1126/science.1152586 | PMID = 18202256 }}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Neuroendocrine nuclear features - round nucleus, no nucleolus, stippled chromatin - '''key feature'''. | |||
*Typically medium size cells ~3x resting lymphocyte. | |||
**May be small or large. | |||
*Arranged in a nested pattern or sheets. | |||
*Scant cytoplasm. | |||
*Abundant mitoses. | |||
*+/-Nuclear moulding. | |||
DDx: | |||
*[[Basal cell carcinoma]] - no stippled chromatin, less mitoses active. | |||
*Cutaneous [[Ewing sarcoma]] - sorted-out with immunostains. | |||
Images: | |||
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ng12hist.htm ] | |||
*[http://www.joplink.net/prev/200403/07.html ] | |||
===IHC=== | |||
Features: | |||
*CK7 -ve. | |||
*CK20 +ve. | |||
*CAM5.2 +ve (dot-like pattern). | |||
Others: | |||
*TTF-1 -ve. | |||
==Dermatofibrosarcoma protuberans== | ==Dermatofibrosarcoma protuberans== | ||
*Abbreviated ''DFSP''. | *Abbreviated ''DFSP''. | ||