Difference between revisions of "Non-malignant skin disease"

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(→‎Granuloma annulare: split "granuloma annulare" into superficial and deep)
(→‎Granuloma annulare: re-work section's micro descript.)
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===Microscopic===
===Microscopic===
Divided into ''subcutaneous'' (superficial?) and ''interstitial'' (deep?).
====Subcutaneous====
Features:<ref name=Ref_WMSP478>{{Ref WMSP|478}}</ref>
Features:<ref name=Ref_WMSP478>{{Ref WMSP|478}}</ref>
*Dermal palisading granuloma around:
*Dermal palisading [[granuloma]] around:
**Mucin - '''key feature'''
**Necrotic collagen - '''key feature'''.
***Nuclei "missing" - have undergone karyolysis.
**Mucin.
***Loose/pale, paucicellular, eosinophilic.
***Loose/pale, paucicellular, eosinophilic.
**Necrotic debris.
*Chronic inflammatory cells.
*Chronic inflammatory cells.


Notes:
Notes:
*There may be multiple small foci with intervening normal dermis.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
#There may be multiple small foci with intervening normal dermis.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
#Granuloma annulare can be subclassified into ''subcutaneous'' and ''interstitial''.
#Histomorphologically similar to ''[[Rheumatoid nodule]].


DDx:
DDx:
*Necrobiosis lipoidica - little mucin, no normal dermis between foci.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
*Necrobiosis lipoidica - little mucin, no normal dermis between foci.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
*[[Rheumatoid nodule]].


Images:
Images:
*[http://www.dermaamin.com/site/histopathology-of-the-skin/61-i/1813-interstitial-granuloma-annulare-.html Granuloma annulare (dermaamin.com)].
*[http://www.dermaamin.com/site/histopathology-of-the-skin/61-i/1813-interstitial-granuloma-annulare-.html Granuloma annulare (dermaamin.com)].
====Interstitial====
Features:<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
*Dermal palisading granuloma around:
**Necrotic collagen - '''key feature'''.
**Mucin.
***Loose/pale, paucicellular, eosinophilic.
*+/-Eosinophils.
Notes:
*Histomorphologically similar to ''[[Rheumatoid nodule]]''.
DDx:
*Necrobiosis lipoidica - little mucin, no normal dermis between foci.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>


==Keloid==
==Keloid==
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