Difference between revisions of "Non-malignant skin disease"

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*6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques.
*6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques.


===Microscopy===
===Gross===
*Wickham striae = white lines/dots.
**Due to hypergranulosis.
 
===Microscopic===
Features:<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref><ref name=Ref_PBoD8_1192>{{Ref PBoD8|1192}}</ref>
Features:<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref><ref name=Ref_PBoD8_1192>{{Ref PBoD8|1192}}</ref>
*Loss of basal cells (stratum basale) -- '''key feature'''.
*Loss of basal cells (stratum basale) -- '''key feature'''.
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*Hypergranulosis; stratum granulosum thickened (grossly seen as "Wickham stria" = white lines).
*Hypergranulosis; stratum granulosum thickened (grossly seen as "Wickham stria" = white lines).
*Hyperkeratosis; stratum corneum thickened.
*Hyperkeratosis; stratum corneum thickened.
*Necrotic basal cell in dermis = colloid bodies = Civatte bodies.<ref>{{Ref PCPBoD8_604}}</ref>


Notes:
Notes:
*Hyperkeratosis and hypergranulosis are not seen in [[erythema multiforme]].
*Hyperkeratosis and hypergranulosis are not seen in [[erythema multiforme]].
*Colloid bodies = cytoid bodies = Civatte bodies = hyaline bodies = apoptotic bodies.<ref>URL: [http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html]. Accessed on: 28 August 2011.</ref>
**DDx: systemic lupus erythematosus, lichen planus, and [[graft-versus-host disease]].


Images:
Images:
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