Difference between revisions of "Inflammatory bowel disease"

Line 11:

*UC patients get pouches... CD patients do not.

**It is said that: ''There 's nothing like a pouch to bring out Crohn's disease''.<ref>URL: [http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf]. 3 March 2011.</ref>

*People with long standing IBD have an increased risk for:

**Carcinoma - usually [[colorectal carcinoma]].<ref name=pmid21640928>{{Cite journal | last1 = Claessen | first1 = MM. | last2 = Siersema | first2 = PD. | last3 = Vleggaar | first3 = FP. | title = IBD-related carcinoma. | journal = Best Pract Res Clin Gastroenterol | volume = 25 Suppl 1 | issue = | pages = S27-38 | month = Apr | year = 2011 | doi = 10.1016/S1521-6918(11)70007-5 | PMID = 21640928 }}</ref>

***Small increased risk for [[small bowel]] adenocarcinoma in Crohn's disease.<ref name=pmid21640928/>

**Lymphoma - in association with thiopurine use.<ref name=pmid21830262>{{Cite journal | last1 = Vos | first1 = AC. | last2 = Bakkal | first2 = N. | last3 = Minnee | first3 = RC. | last4 = Casparie | first4 = MK. | last5 = de Jong | first5 = DJ. | last6 = Dijkstra | first6 = G. | last7 = Stokkers | first7 = P. | last8 = van Bodegraven | first8 = AA. | last9 = Pierik | first9 = M. | title = Risk of malignant lymphoma in patients with inflammatory bowel diseases: A Dutch nationwide study. | journal = Inflamm Bowel Dis | volume = 17 | issue = 9 | pages = 1837-1845 | month = Sep | year = 2011 | doi = 10.1002/ibd.21582 | PMID = 21830262 }}</ref>

===Molecular===

*NOD2/CARD15 variants are assoc. with stricturing CD, early need for surgery and recurrence.<ref name=pmid16244543 >{{cite journal |author=Alvarez-Lobos M, Arostegui JI, Sans M, ''et al.'' |title=Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence |journal=Ann. Surg. |volume=242 |issue=5 |pages=693–700 |year=2005 |month=November |pmid=16244543 |pmc=1409853 |doi= |url=}}</ref>

===General clinical differential diagnosis===

Line 21:

Line 28:

Others:

*[[Irritable bowel syndrome]].

~~==Epidemiology==~~

*NOD2/CARD15 variants are assoc. with stricturing CD, early need for surgery and recurrence.<ref name=pmid16244543 >{{cite journal |author=Alvarez-Lobos M, Arostegui JI, Sans M, ''et al.'' |title=Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence |journal=Ann. Surg. |volume=242 |issue=5 |pages=693–700 |year=2005 |month=November |pmid=16244543 |pmc=1409853 |doi= |url=}}</ref>

==Microscopic==

Difference between revisions of "Inflammatory bowel disease"

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@@ Line 11: / Line 11: @@
 *UC patients get pouches... CD patients do not.
 **It is said that: ''There 's nothing like a pouch to bring out Crohn's disease''.<ref>URL: [http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf]. 3 March 2011.</ref>
+*People with long standing IBD have an increased risk for:
+**Carcinoma - usually [[colorectal carcinoma]].<ref name=pmid21640928>{{Cite journal  | last1 = Claessen | first1 = MM. | last2 = Siersema | first2 = PD. | last3 = Vleggaar | first3 = FP. | title = IBD-related carcinoma. | journal = Best Pract Res Clin Gastroenterol | volume = 25 Suppl 1 | issue =  | pages = S27-38 | month = Apr | year = 2011 | doi = 10.1016/S1521-6918(11)70007-5 | PMID = 21640928 }}</ref>
+***Small increased risk for [[small bowel]] adenocarcinoma in Crohn's disease.<ref name=pmid21640928/>
+**Lymphoma - in association with thiopurine use.<ref name=pmid21830262>{{Cite journal  | last1 = Vos | first1 = AC. | last2 = Bakkal | first2 = N. | last3 = Minnee | first3 = RC. | last4 = Casparie | first4 = MK. | last5 = de Jong | first5 = DJ. | last6 = Dijkstra | first6 = G. | last7 = Stokkers | first7 = P. | last8 = van Bodegraven | first8 = AA. | last9 = Pierik | first9 = M. | title = Risk of malignant lymphoma in patients with inflammatory bowel diseases: A Dutch nationwide study. | journal = Inflamm Bowel Dis | volume = 17 | issue = 9 | pages = 1837-1845 | month = Sep | year = 2011 | doi = 10.1002/ibd.21582 | PMID = 21830262 }}</ref>
+===Molecular===
+*NOD2/CARD15 variants are assoc. with stricturing CD, early need for surgery and recurrence.<ref name=pmid16244543 >{{cite journal |author=Alvarez-Lobos M, Arostegui JI, Sans M, ''et al.'' |title=Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence |journal=Ann. Surg. |volume=242 |issue=5 |pages=693–700 |year=2005 |month=November |pmid=16244543 |pmc=1409853 |doi= |url=}}</ref>
 ===General clinical differential diagnosis===
@@ Line 21: / Line 28: @@
 Others:
 *[[Irritable bowel syndrome]].
-==Epidemiology==
-*NOD2/CARD15 variants are assoc. with stricturing CD, early need for surgery and recurrence.<ref name=pmid16244543 >{{cite journal |author=Alvarez-Lobos M, Arostegui JI, Sans M, ''et al.'' |title=Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence |journal=Ann. Surg. |volume=242 |issue=5 |pages=693–700 |year=2005 |month=November |pmid=16244543 |pmc=1409853 |doi= |url=}}</ref>
 ==Microscopic==